冻融胚胎移植的临床应用  

Clinical application of cryopreservation thawed embryos

作　　者：周伟方[1] 丁亚军[1] 谢建华[1] 周黎明[1] 赵雅云[1] 孙亦婷[1] 王华[1] 陈剑茹[1] 

机构地区：[1]宁波市妇女儿童医院,315010

出　　处：《现代实用医学》2003年第2期85-87,共3页Modern Practical Medicine

基　　金：宁波市科委科研项目 (编号 :2 0 0 0 3 9)

摘　　要：目的　积累体外受精冻融胚胎移植技术的经验。　方法　对 2 0例在体外受精形成的多个胚胎 ,在移植后将剩余胚胎全部冷冻保存 ,如本周期未获妊娠 ,在以后的周期再行解冻移植。　结果　 2 0例进行2 0个周期的冻融胚胎移植 ,获临床妊娠 7例 ,临床妊娠率为 35 %。其中自然周期移植 13例获临床妊娠 5例 ,妊娠率为 38.5 % ;激素替代周期 7例 ,获临床妊娠 2例 ,妊娠率为 2 8.5 %。首例冻融胚胎于 2 0 0 2年 6月2 8日孕 38周分娩一男婴 ,新生儿发育良好。　结论　采取冻融胚胎移植可提高累积妊娠率 。Objective To accumulate experience of cryopreservation thawed embryo transfer in vitro fertilization. Methods The surplus embryos after in vitro fertilization and embryo transplantation (in 20 cases) were all cryopreservated. Given invalidated pregnancy, they would be thawed in a later cycle for another transplantation. Results Among the 20 cases who had received cryopreservation thawed embryo transplantation for 20 cycles, 7 cases achieved clinical pregnancy (with the rate of 35%). Out of the 20 cases, 13 cases received natural-cycle transplantation and 5 of them achieved clinical pregnancy (with the rate of 38.5 %); 7 cases received hormone substitution transplantation and 2 of them achieved clinical pregnancy (with the rate of 28.5 %). In the first case of cryopreservation thawed embryo pregnancy, a boy infant was delivered after 38 weeks conception and the neonate developed well. Conclusion Cryopreservation thawed embryo transplantation can increase the chance of accumutive pregnancy while curb the occurrence of multi pregnancy and the syndrome of excessive ovary stimulation.

关 键 词：冻融胚胎移植 临床应用 体外受精 妊娠 

分 类 号：R321－33[医药卫生—人体解剖和组织胚胎学]