慢性应激对大鼠空间学习记忆和海马一氧化氮的影响  

Effects of Chronic Stress on Spatial Learning and Memory and Nitric Oxide in Hippocampus of Rats

作　　者：胡旺平[1] 李雪梅[1] 胡圣望[1] 化长林[1] 

机构地区：[1]咸宁医学院生理学教研室,437100

出　　处：《中国心理卫生杂志》2003年第2期75-76,共2页Chinese Mental Health Journal

基　　金：湖北省教育厅重点课题资助项目 (№A0 4 0 0 3)

摘　　要：目的 :探讨慢性应激对大鼠空间学习记忆和海马NO的影响。方法 :采用电击足底结合噪声建立慢性应激大鼠模型 ,Morris水迷宫观察动物的学习和记忆能力 ,同时检测海马NO含量和NOS活性。结果 :慢性应激大鼠在Morris水迷宫的空间学习和记忆能力明显下降 ,海马NO含量和NOS活性 (3 87± 0 47nmol/mgpro和 10 2 64± 13 33pmol/mgpro/min)显著高于对照组大鼠 (2 76± 0 43nmol/mgpro和 78 2 5± 10 67pmol/mgpro/min)。结论 :慢性应激损害大鼠空间学习和记忆能力 。Objective: To study the effect of chronic stress on spatial learning and memory and nitric oxide (NO) in hippocampus of the rats Method: Chronic stress model was established by electric-foot accompanied with noise Morris watermaze was used to observe spatial learning and memory abilities, contents of NO and activities of NOS in hippocampus were measured during the test Result: The spatial learning and memory of chronic stress rats were significantly decreased in Morris watermaze Contents of NO (3 87±0 47 nmol/mgpro) and NOS activity (102 64±13 33 pmol/mgpro/min) in hippocampus of the stress rats were significantly higher than that of normal rats (2 76±0 43 nmol/mgpro, 78 25±10 67 pmol/mgpro/min respectively) Conclusion: Chronic stress impairs spatial learning and memory abilities of rats, which may be related to the increase of NO in their hippocampus

关 键 词：慢性应激 大鼠 空间学习 空间记忆 海马 一氧化氮 

分 类 号：R338.64[医药卫生—人体生理学] B842.3[医药卫生—基础医学]