阻塞性睡眠呼吸暂停低通气综合征60例临床分析  

On the Clinical Features of the Obstructive Sleep Apnea-hypopnea Syndrome:A Analysis of 60 Cases

作　　者：杨朝[1] 张锦[1] 魏艳萍[1] 

机构地区：[1]宁夏医学院附属医院呼吸科,银川750004

出　　处：《宁夏医学院学报》2003年第1期13-15,共3页Journal of Ningxia Medical College

摘　　要：目的 :阻塞性睡眠呼吸暂停低通气综合征 (OSAHS)是一种严重的通气道阻塞病征 ,本文综合分析其临床特征并评价其意义。方法 :对 2 0 0 1年 1月～ 2 0 0 2年 1月期间 6 0例OSAHS患者的肺功能、心功能、生化指标和血氧饱和度分别用SENSORMEDICS6 2 0 0 ,AGILENTSONOS4 5 0 0BECKMANCX9和睡眠监测仪PSG等仪器测定 ,血压和血尿常规用手工法测定。结果 :①OSAHS患者主要表现为多器官功能损害 :如高血压、心、肺、肾功能损害 ,红细胞增多 ,血糖、血脂、血尿酸升高。②各器官系统损害有一定的特点 :如肺功能损害多以通气功能受损为主 ;心功能损害多为血压升高 ,超声心动图改变符合高血压、肺心病及冠心病性改变 ;肾功能损害多为夜尿增多及蛋白尿并且治疗后可逆转。③红细胞增多、血糖、血脂、血尿酸升高可加重上述损害 ,形成恶性循环。结论 :OSAHS导致的低氧血症及高碳酸血症可造成多器官系统损害 ,临床应充分认识 ,早期、合理、有效治疗可逆转或阻止多器官功能的进一步损害 ,明显改善预后。Objective:Obstructive sleep apnea-hypopnea syndrome ( OSAHS ) is a serious condition in which airflow from the nose and mouth to the lungs is restricted during sleep.It is characteristically associated with loud snoring.This paper was to sum up the clinical featrues of OSAHS and to analyze their clinical implication.Methods:Over the past one year (from Jan 2001 through Jan 2002),60 patients with OSAHS were consecutively enrolled in this study.Their pulmonary functions,cardiac function,biochemical parameters and oxygen saturation of blood were determined by instruments SENSORMEDICS 6200,AGILENTSONOS 4500 BECKMAN CX9 and somnocinematograph PSG respectively,and blood pressure,blood-urine routine examinations were done manually.Results:The OSAHS patients'cardinal manifestation were functional abnormalities of certain organs i.e.dysfunction of heart,lung and kidney and increases of RBC,blood glucose,lipid and trioxypurine.Each organic injury revealed its own specific features and was related to its own original dysfunction;ventilation restriction,hypertension,ultrasonogram alteration and proteinurea indicated individually the respective organ involvement in the OSAHS pathogenesis.The increases of RBC, glucose lipid and uric acid deteriorated further the functional disturbance of heart,lung and kidney and eventurally vicious circle was resulted.Conclusion:Hypoxemia and hypercarbia of OSAHS patients can cause various organs functional disturbance.The early treatments were critically important because they can reverse or prevent these function from being further deteriorated and therefore improve patients'prognosis.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 临床分析 临床特征 肺功能 心功能 生化指标 血氧饱和度 0SAHS 

分 类 号：R56[医药卫生—呼吸系统]