同种异体骨移植治疗骨缺损的临床应用  

Clinical application of allograft in the treatment of bone defects

作　　者：黎早敏[1] 宋世峰[1] 林坚平[1] 姚伦龙[1] 曾凡[1] 郑南生[1] 许世忠[1] 陈世强[1] 

机构地区：[1]海南省人民医院创伤骨科,海口570311

出　　处：《海南医学》2003年第3期6-8,共3页Hainan Medical Journal

摘　　要：目的　观察异体骨移植治疗骨缺损的临床疗效。方法　 2 1例骨缺损病人 ,年龄 7至 5 6岁 ,创伤性骨缺损 15例 ,肿瘤性骨缺损 6例 ,采用山西省医用组织库提供的同种异体骨移植 ,其中大段骨移植 1例 ,骨块 +骨条移植 11例 ,骨条移植 9例 ,术后观察切口愈合等级 ,免疫排斥反应的表现 ,骨缺损愈合情况及异体骨移植的并发症。结果　 2 1例病人随访 2至 18个月 ,切口甲级愈合 16例 ,乙级愈合 4例 ,术后感染丙级愈合 1例。移植骨愈合 19例 ,移植骨部分吸收 1例 ,1例随访时间 65天 ,移植骨尚未愈合。结论　小块异体骨移植可获得自体骨移植的同样疗效 ,未观察到明显的免疫排斥反应 ,大段骨移植疗效尚待观察。s objective To investigate the clinical effects of allograft in the treatment of bone defects.Methods:21 cases of patients including 15 cases of traumatic bone defects and 6 cases of tumorous bone defects,aged 7 to 56 years old,were treated by allograft which come from Medical Tissue Bank of Shanxi Province in china,in which 1 case of long segmental allograft?11 cases of bone block and bone strip allograft and 9 cases of bone strip allograft postoperative wound union?manifestation of immuno-rejection?union of bone defects and complication were observed.Results:21 cases were followed for 2 to 18 months.incision union of the first rate happened in 16 case,the second rate in 4 cases and 1 case showed postoperative infection of wound.19 cases displayed union of allograft and 1 case showed segmental resorption.1 case was followed for 65 days,butnon-union happened.Discussion:Small piece of allograft can receive the same therapeutic results as that of autograft and no obvious immuno-rejection was found.The effect oflarge segmental allograft is waiting for observation.

关 键 词：同种异体骨移植 治疗 骨缺损 临床应用 疗效 创伤性 肿瘤性 免疫排斥反应 并发症 

分 类 号：R683[医药卫生—骨科学]