喹赛多对家禽常见病原菌的体外抗菌活性研究  

In vitro Antibacterial Activity of Cyadox on Poultry Bacteria

作　　者：黄玲利[1] 袁宗辉[1] 范盛先[1] 刘登才[1] 陈品[1] 王大菊[1] 

机构地区：[1]华中农业大学兽药研究所,湖北武汉430070

出　　处：《华南农业大学学报》2003年第2期81-83,共3页Journal of South China Agricultural University

基　　金：九五"国家重点科技攻关计划资助项目(96-009-02-04-05)

摘　　要：采用试管二倍稀释法测定喹赛多对家禽6种13株常见病原菌的体外抑菌活性.结果表明:喹赛多对家禽革兰氏阳性菌和革兰氏阴性菌均有较强的抑制作用,对鸡大肠杆菌、金黄色葡萄球菌和沙门氏菌抑菌活性最明显,其最小抑菌浓度(MIC)分别为0 62、1 25和0 62μg/mL.该药对大肠杆菌还表现出杀菌活性,最小杀菌浓度(MBC)≥80μg/mL.喹赛多抗菌活性与喹乙醇相近,强于磺胺二甲嘧啶,比盐酸金霉素略差.这些结果表明,喹赛多是一种活性较强的抑菌剂,可推荐用作家禽常见病原菌感染的预防药物.The in vitro antibacterial activity of cyadox on 6 species 13 strains of clinical pathogenic bacteria in poultry was tested by microdilution method.The results showed that cyadox was active both on grampositiv bacteria and gramnegative bacteria, and more active on Escherichia coli, Staphylococcus aureus and Salmonella spp. than the others. The MIC of these was 0.62, 1.25 and 0.62 μg/mL respectively. It showed germicidal action only on Escherichia coli, the MBC≥80 μg/mL. The antibacterial activity of cyadox was similar to that of olaquindox, stronger than that of sulfadimidine, and weaker than that of aureomycin. These results indicated that cyadox had strong bacteriostatic activity, and could be used as a drug additive to protect poultry from bacterial infection in the field.

关 键 词：喹赛多 家禽 病原菌 体外抗菌活性 试管二倍稀释法 抗病促生长药物添加剂 

分 类 号：S816.75[农业科学—饲料科学]