七-(2,3,6,-O-烯丙基)-β-环糊精的合成与表征  

Synthesis and Characterization of Heptakis-(2,3,6-O-allyl)-β-CD

作　　者：张蓉[1] 赵邦蓉[2] 

机构地区：[1]太原理工大学化工学院应化系,山西太原030024 [2]北京化工大学应用化学系,北京100029

出　　处：《合成化学》2003年第2期178-180,共3页Chinese Journal of Synthetic Chemistry

摘　　要：利用氢氧化钠作催化剂使 β 环糊精 (简称 β CD)被烯丙基修饰合成了七 (2 ,3,6 O 烯丙基 ) β 环糊精[Heptakis (2 ,3,6 O allyl) β CD]。用正交实验法考察了反应温度、反应时间、催化剂用量和修饰剂———烯丙基溴用量等因素对合成目标化合物的影响 ,得出合成七 (2 ,3,6 O 烯丙基 ) β 环糊精的最佳实验条件 :n(β 环糊精 )∶n(烯丙基溴 ) =1∶86 .92 ,n(催化剂 )∶n(烯丙基溴 ) =1∶1.0 5 2。产物经元素分析 ,IR和1Heptakis (2,3,6 O allyl) β CD have been synthesized by modification of β CD with ally bromide using NaOH as a catalyst. The influence of the reaction temperature and time, the amount of the catalyst and ally bromide on the synthesis was investigated. The optimum experimental conditions were established by the method of orthogonal experiment as follows: n(β CD)∶n(ally bromide)=1∶86.92, n(NaOH)∶n(ally bromide)=1∶1.052. The target compound was characterized by elemental analysis, IR, 1H NMR and FAB MS.

关 键 词：七-(2 3 6 -0-烯丙基)-β-环糊精 合成 正交实验法 表征 

分 类 号：O636.12[理学—高分子化学]