基于表面活性效应多壁碳纳米管修饰电极测定戊酸雌二醇  

Voltammetric Determination of Estradiol Valerate by Using Multi-Wall Carbon Nanotubes-Modified Electrode Based on the Enhancement Effects of Surfactant

作　　者：孙延一[1] 吴康兵[1] 胡胜水[1] 

机构地区：[1]武汉大学化学与分子科学学院,湖北武汉430072

出　　处：《武汉大学学报（理学版）》2002年第6期685-688,共4页Journal of Wuhan University:Natural Science Edition

基　　金：国家自然科学基金 ( 6 0 1710 2 3);湖北省重点项目 ( 992P0 5 15 );湖北省自然科学基金资助项目 ( 99J0 6 6 )

摘　　要：研究了戊酸雌二醇在表面活性剂存在下 ,在多壁碳纳米管修饰玻碳电极上的电化学行为 ,发现表面活性剂能显著提高戊酸雌二醇的氧化电流 基于此 ,建立了一种直接测定戊酸雌二醇的电化学方法 优化了测定参数 ,如 :介质的 pH值 ,修饰剂的用量 ,扫描速度 ,富集电位和富集时间 ,表面活性剂的种类及其浓度等 峰电流与戊酸雌二醇在 1× 10 -7～ 2 .5× 10 -5mol·L-1的浓度范围内有良好的线性关系 ,检测限为 4× 10 -8mol·L-1 1× 10 -5mol·L-1戊酸雌二醇平行测定 8次的标准偏差为 4.5 % 用多壁碳纳米管修饰电极测定了戊酸雌二醇注射液中戊酸雌二醇的含量 ,取得了满意的结果 .The multi-wall carbon nanotubes (MWNT)-modified glassy carbon electrode (GCE) was fabricated for the determination of estradiol valerate (EV) in the presence of anionic surfactant such as sodium dodecylbenzene sulfinate (SDBS). In the presence of 2×10 -4 mol·L -1 SDBS, the oxidation peak current of EV at the MWNT-modified GCE increases significantly in comparison to that at the bare GCE. The experimental parameters were optimized. Accumulation was carried out under open-circuit condition since accumulation potential has no influence on the oxidation of EV. The interferences of some common metal ions and organic compounds on the oxidation peak current of EV were investigated. The peak current is proportional to the concentration of EV over the range from 1×10 -7 to 2.5×10 -5 mol·L -1. The detection limit is 4×10 -8 mol·L -1 at 4 min accumulation. The relative standard deviation (RSD) of eight measurements, which measured at one single electrode, is 4.5% for 1×10 -5 mol·L -1 EV. Using this modified electrode, EV in the injection samples was detected.

关 键 词：戊酸雌二醇 化学修饰电极 多壁碳纳米管 表面活性效应 电化学测定 雌性激素类药物 

分 类 号：R977.12[医药卫生—药品] R927[医药卫生—药学]