双嘧达莫的协同荧光增敏光谱分析法研究  

Study on the Enhanced Fluorescence Spectrum Analysis Method of Dipyridamole

作　　者：颜承农[1] 潘祖亭[2] 杨洗[2] 曹建军[2] 

机构地区：[1]荆州师范学院化学系,湖北荆州434100 [2]武汉大学化学与分子科学学院,湖北武汉430072

出　　处：《武汉大学学报（理学版）》2002年第6期694-696,共3页Journal of Wuhan University:Natural Science Edition

基　　金：湖北省教育厅科学研究资助项目 ( 2 0 0 1A410 0 5 )

摘　　要：以荧光光谱法研究了三羟甲基氨基甲烷 盐酸 (Tris HCl)缓冲溶液和溴化十六烷基三甲铵 (CTMAB)、Tris HCl缓冲溶液和β 环糊精 (β CD)两体系对双嘧达莫的协同荧光增敏作用 ,提出了在此条件下用协同荧光增敏光谱分析法测定双嘧达莫含量的新方法 本法灵敏度高 ,检测限低 (9.2 0× 10 -9mol/L) ,在 7.92 6× 10 -8～ 2 .378× 10 -6mol/L范围内荧光强度与双嘧达莫的浓度呈良好线性关系 .The spectral properties of dipyridamole were studied in the presence of CTMAB,β-CD by the fluorescence spectroanalysis.It was found that the fluorescence intensity of dipyridamole was greatly enhanced in the systems of CTMAB-Tris andβ-CD-Tris.A new fluorescence spectroanalysis method was established for determining dipyridamole in aqueous solution with high selectivity and specificity.

关 键 词：双嘧达莫 协同荧光增敏光谱分析法 含量测定 药物分析 抗高血压药 

分 类 号：R972.4[医药卫生—药品] R927.[医药卫生—药学]