危重病患者血清细胞因子水平的动态变化及临床意义  

Changes and clinical significance of plasma cytokines in critically ill patients

作　　者：乔万海[1] 裴红红[1] 李小珍[1] 封英群[1] 

机构地区：[1]西安交通大学第二医院急诊科,西安710004

出　　处：《中华急诊医学杂志》2003年第2期109-110,共2页Chinese Journal of Emergency Medicine

基　　金：西安市科委资助项目 (YG2 0 0 115 )

摘　　要：目的　探讨危重患者血清细胞因子IL 6、TNF α的动态变化及临床意义。方法　采用ELISA法测定 35例危重患者IL 6及TNF α的动态变化并与正常对照组进行比较。结果　 35例患者血清IL 6、TNF α于 2 4h内即显著升高 ,较正常对照组差异显著 ,以后呈波动性变化 ,于第 6天出现第 2次高峰。结论　细胞因子参与了SIRS向MODS的发生发展 ,IL 6、TNFObjective To study the changes and clinical significance of plasma cytokines interleukin 6(IL 6) and tumor necrosis factor α(TNF α)in critically ill patients.Methods By using enzyme linked immunosorbent assay(ELISA)method,plasma IL 6?TNF α levels were measured in 35 critically ill patients,compared to healthy controls.Results Within 24 h,plasma IL 6 and TNF α levels were significantly higher in the patients compared with healthy control.Afterwards,the cytokine levels fluctuated reaching a second peak on day 6.Conclusion Cytokines IL 6 and TNF α play important roles in the development from SIRS to MODS.The chauges in their levels are probably important in the diagnosis of MODS. [

关 键 词：全身炎性反应综合征 多脏器功能障碍综合征 细胞因子 IL-6 TNF—α 临床意义 ELISA法 

分 类 号：R446.6[医药卫生—诊断学]