农药四螨嗪合成新工艺的研究  

Study on A New Process for Synthesis of Clofentezine A Pesticide

作　　者：饶国武[1] 周欣[1] 杨忠愚[1] 胡惟孝[1] 

机构地区：[1]浙江工业大学制药工程研究所,杭州310014

出　　处：《农药》2003年第2期13-14,共2页Agrochemicals

摘　　要：从邻氯苯甲醛出发 ,经缩合、氯代、环合、氧化四步制得农药杀虫剂 3 ,6-双 (2 -氯苯基 )- 1,2 ,4,5 -四嗪。并用正交设计法对氯代过程进行优化 ,得出最佳工艺为 :双 (2 -氯苯亚甲基 )肼和冰醋酸投料比为 10g∶3 5ml,温度 2 0℃ ,搅拌时产率最高 ,为 84 5 % ,全程收率为 5 9 3 % ,而现有生产工艺邻氯苯甲酰氯法的总收率为 13 2 %。The pesticide 3,6-bis(2-chlorophenyl)-1,2,4,5-tetrazine has been prepared by condensation,chloration,cyclication and oxidation from 2-chlorobenzaldehyde and hydrazine hydrate The operation conditions for the chloration are optimized by optimum seeking method The optimum conditions were as follows:m(bis(2-chlorobenzylidene)hydrazine)∶v(acetic acid)= 10g∶35ml,in 20℃ with stirring,the yield reaches 84 5% The overall yield reaches as high as 59 3% comparing with 13 2% in the literature of the method with 2-chlorobenzoyl chloride

关 键 词：农药 四螨嗪 合成 新工艺 研究 正交设计法 

分 类 号：TQ454[化学工程—农药化工]