美多心安-β-环糊精包合物的核磁光谱研究  

Confirmation of metoprolol/β- cyclodextrin inclusion compound by nuclear magnetic resonance

作　　者：姬小明[1] 杨新玲[1] 张广明[2] 

机构地区：[1]郑州牧业工程高等专科学校,河南郑州450008 [2]郑州大学化学系,河南郑州450052

出　　处：《河南科学》2003年第1期42-44,共3页Henan Science

摘　　要：通过共沉淀法制备了美多心安-β-环糊精包合物,并用核磁共振谱图加以鉴定,证明了美多心安和β-环糊精能够形成包合物,且包合物中主客分子比为2:1。Metoprolol/cyclodextrin inclusion compound was prepared by the co - precipitation method, and its structure was examined by 1HNMR, The formation of the inclusion compound was proved, The ratio of host to guest is 2:1 in inclusion compound.

关 键 词：美多心安-β-环糊精包合物 抗心律失常药 核磁共振谱图 共沉淀法 制备 

分 类 号：R972.2[医药卫生—药品] R914[医药卫生—药学]