鼠、犬、人等哺乳动物全血体外放置时间对其血液流变特性的影响  

Effects of storing time of blood in vitro on mammalian hemorheological characteristics

作　　者：张建保[1] 王南林[1] 张晓军[1] 巨宏博[1] 范云[1] 杨继庆[1] 屈学民[1] 龙开平[1] 王斯刚[1] 

机构地区：[1]第四军医大学生物医学工程系物理学教研室,陕西西安710033

出　　处：《第四军医大学学报》2003年第3期200-202,共3页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金 (1 990 2 0 2 0 )

摘　　要：目的 :研究不同哺乳动物体外血放置 2 4h对血流变学指标的影响 .方法 :检测不同时间点的全血高切、低切表观粘度及红细胞聚集指数、刚性指数 .结果 :随血液体外放置时间的延长 ,不同动物 (小鼠、大鼠、家犬、豚鼠 )的全血高切、低切表观粘度及红细胞聚集指数、刚性指数均可产生显著变化 (P <0 .0 5 ) ,而且变化的临界时间及变化趋势明显不同 .结论 :动物血液在体外随时间的变化其流变特性会发生明显变化 ,因而动物血液流变学的相关实验必须注意体外放置时间的影响 .AIM: To study the effects of the storing time of 24 h on hemorheology when various mammalians blood was stored in vitro . METHODS: Whole blood apparent viscosity, aggregation index and rigidity index of red blood cells were measured. RESULTS: The hemorheological performance of rats, mice, dogs and guinea pigs changed significantly with the lengthening of storing time and the threshold time and changing characteristics varied with the diffe rent animals. CONCLUSION: The performance of hemorheology will change significantly( P <0.05)with the prolongation of storing time in vitro and the storing time will be considered when related experiments are to be performed.

关 键 词：哺乳动物 全血 体外放置 放置时间 血液流变学 影响 红细胞聚集指数 刚性指数 

分 类 号：R331.1[医药卫生—人体生理学]