幽门螺杆菌疫苗研究的现状和展望  

Recent developments in Helicobacter pylori vaccination

作　　者：陈旻湖[1] 焦志勇[1] 

机构地区：[1]中山大学附属第一医院消化内科,广州510080

出　　处：《临床内科杂志》2003年第2期63-65,共3页Journal of Clinical Internal Medicine

摘　　要：幽门螺杆菌感染与慢性胃炎、消化性溃疡、胃癌及胃粘膜相关性淋巴瘤有关。疫苗是防治幽门螺杆菌感染切实可行的方法。近年来新的防治和根除幽门螺杆菌感染的疫苗正在开发并取得了很大的进展。本文对新近研制的蛋白组分疫苗、活菌疫苗、DNA疫苗、缓释微球疫苗及表位疫苗等幽门螺杆菌疫苗的进展作一综述。Helicobacter pylori infection is associated with chronic gastritis,peptic ulcer disease,gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. Vaccination is a feasible method against Hp infection. Recently new vaccination strategies for the prevention and eradication of Hp infections are being explored. Great progresses were obtained in this field. This review discussed newly developed vaccines against Hp infection such as protein component vaccine, gene-engineering bacterial vaccine,DNA vaccine, controlled release microparticles vaccine, epitope vaccine.

关 键 词：幽门螺杆菌感染 疫苗 现状 展望 蛋白组分疫苗 活菌疫苗 DNA疫苗 缓释微球疫苗 表位疫苗 

分 类 号：R392[医药卫生—免疫学]