新生儿抗生素相关性腹泻的临床研究  

Antibiotic-related Diarrhea in the Newborns:the Clinical Research and Countermeasure

作　　者：张小莉[1] 张香莲[2] 张青[2] 王俊英[2] 

机构地区：[1]山西医科大学儿科系,山西太原030001 [2]山西省儿童医院,山西太原030013

出　　处：《中华医院感染学杂志》2003年第1期60-61,共2页Chinese Journal of Nosocomiology

摘　　要：目的　探讨新生儿抗生素相关性腹泻的发病率、发病因素及微生态疗法的临床作用。方法　对山西省儿童医院新生儿内科 2 0 0 2年 1月 1日～ 3月 3 1日住院患者进行了抗生素使用、抗生素相关性腹泻的发生率及发病因素和其他相关临床资料的调查 ,并将其作为对照组 ,2 0 0 2年 4月住院并具完整病历的出院患者作为服药组 ,观察微生态制剂贝飞达 (双歧三联活菌制剂 )对抗生素相关性腹泻的预防作用。结果　抗生素相关性腹泻的发生率达 2 4.5 4% ,不合理使用抗生素是导致这一结果的主要原因 ,微生态制剂对防止抗生素相关性腹泻有一定作用。结论　减少广谱抗生素的使用、减少联合用药和避免住院时间过长、辅之以微生态制剂 ,可有效减少抗生素相关性腹泻的发生 ,后者还可通过免疫调节功能而促进原发疾病临床康复 。OBJECTIVE To investigate the incidence, relative factors of antibiotic related diarrhea and the effect of microbiotic therapy in the newborns. METHODS To study the usage of antibiotic, incidence of antibiotic related diarrhea and other clinical data in Newborn Department, Shanxi Children′s Hospital during 3 months (from Jan. to March 2002) and use these cases as the control group. The therapy group are cases who were in hospital during 1 month (1 Apr 2002) and received the microbiotic therapy to study the effect on preventing antibiotic related diarrhea of Bifido. RESULTS The incidence of antibiotic related diarrhea is 24.54%. The main reason leading to this result is unreasonable usage of antibiotics. The microbiotic therapy has a definite effect in controlling this kind of diarrhea. CONCLUSIONS To reduce the usage of broad spectrum and combined antibiotics as well as the too long time in hospital and meanwhile to use the microbiotic therapy is helpful to control the antibiotic related diarrhea. The microbiotic therapy could promote the recovery from initial disease by immune regulation so that the time and the payment could be reduced in the hospital.

关 键 词：新生儿 抗生素相关性腹泻 临床研究 发病率 发病因素 诊断 治疗 

分 类 号：R722[医药卫生—儿科]