硫酸镁预处理对氯胺酮麻醉兔心血管反应及血中儿茶酚胺的影响  

EFFECTS OF PRETREATMENT WITH SULFATE MAGNESIUM ON CARDIOVASCULAR AND PLASMA CATECHOLAMINE DURING KETAMINE ANESTHESIA

作　　者：吴灵潝[1] 周青山[1] 邹捍东[1] 王龙[1] 黄海波[1] 

机构地区：[1]武汉大学人民医院麻醉科,武汉430060

出　　处：《中国现代医学杂志》2003年第3期54-55,共2页China Journal of Modern Medicine

摘　　要：目的 :观察镁预处理对氯胺酮麻醉兔心血管反应及血中儿茶酚胺的影响。方法 :12只家兔麻醉后随机分为两组 ,氯胺酮组 (组Ⅰ )和硫酸镁 -氯胺酮组 (组Ⅱ )。组Ⅰ单次静注氯胺酮 2mg/kg ,组Ⅱ单次静注 2 5 %硫酸镁 14 0mg/kg和氯胺酮 2mg/kg ,连续观察HR ,节律和MAP的变化 ,并于注药前、注药后 10min ,2 0min采动脉血测定血浆去甲肾上腺素 (NA)和肾上腺素 (A)。结果 :组Ⅰ有 2只动物出现偶发室性早搏 ,组Ⅱ未见异位节律 ;注药后 10min组ⅠHR ,MAP ,NA和A明显高于组Ⅱ。结论 :镁用作氯胺酮麻醉前处理能减轻机体的应激反应 ,保持心血管功能的稳定性 ,但机体应激反应低下时 ,应注意两药合用对心血管功能抑制的协同作用。Objective:To observe the effect of pretreatment with sulfate magnesium on ardiovascular and plasma catecholamine during ketamine anesthesia.Methods:We divided 12 rabbits randomly into two groups:group Ⅰ(n=6) and group Ⅱ(n=6).In group Ⅰ 1% ketamine 2mg/kg was injected intravenously after 25% magnesium 140mg/kg Ⅳ.In group Ⅱ,sulfate magnesium was substituted by equivalent volume of normal salts.Result:In group Ⅰ,HR,MAP,NA,A increased significantly after ketamine Ⅳ 10min compared with that of group Ⅱ.Conclusion:It is suggested that ketamine anesthesia with pretreatment of sulfate magnesium may maintian cardiovascular stability.

关 键 词：硫酸镁 预处理 氯胺酮 麻醉 兔 心血管反应 血 儿茶酚胺 

分 类 号：R614[医药卫生—麻醉学]