IL-2对抗精子抗体大鼠精子顶体酶活力的影响  

Effect of IL-2 on the sperm acrosin activity in antisperm antibody positive rat

作　　者：张大勇[1] 张玮[1] 温海霞[1] 边淑玲[1] 倪江[1] 

机构地区：[1]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2003年第1期34-35,共2页Journal of Harbin Medical University

摘　　要：目的　研究IL 2对抗精子抗体阳性大鼠的精子顶体酶活力的影响。方法　精子顶体酶的活力检测采用BAEE ADH联合法。结果　抗精子抗体 (AsAb)阳性大鼠精子顶体酶的活性显著降低 ;IL 2可显著降低AsAb阳性大鼠精子顶体酶的活性 (P <0 .0 0 1) ;AsAb阳性精子的SOD酶活性降低 (P <0 .0 0 1) ;IL 2可使精子中的SOD酶活性降低 (P <0 .0 0 1) ,增强了氧自由基的产生。结论　IL 2对精子顶体酶活性有显著影响。Objective To investigate the effect of IL 2 on the sperm acrosin activity in positive antisperm antibody rat.Methods The sperm acrosin activity was detected by BAEE/ADH method.Results IL 2 decreased the sperm acrosin activity in positive rat ( P <0.001).The results also indicated that IL 2 significantly decreased the SOD activity ( P <0.001) and increased oxygen free radicals of sperms.Conclusion IL 2 could influence the sperm acrosin activity.

关 键 词：男性不育症 抗精子抗体 IL-2 BAEE/ADH联合法 精子顶体酶 SOD酶 氧自由基 动物实验 

分 类 号：R698.2[医药卫生—泌尿科学] R321.1[医药卫生—外科学]