26例妊娠肝内胆汁淤积综合征患者预后临床分析  

Clinical prognostic analysis of 26 patients with intrahepatic cholestasis of pregnancy

作　　者：何红[1] 赵汝珠[1] 刘志杰[1] 

机构地区：[1]兰州军区兰州总医院妇产科,甘肃兰州730050

出　　处：《西北国防医学杂志》2003年第1期33-35,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的 :探讨血清总胆汁酸 (TBA)水平对妊娠肝内胆汁淤积征 (ICP)患者及胎儿预后的影响。方法 :1999- 0 1～ 2 0 0 1- 0 6收治的 2 6例ICP孕妇按TBA值分为胆淤轻型和胆淤重型组 ,与同期正常妊娠的 40例孕妇作对照研究。结果 :三组间分娩孕周、分娩方式、羊水污染、新生儿体重及产后出血量有显著差异 (P <0 .0 5 ) ,新生儿出生后Apgar评分三组间无显著差异。结论 :ICP对母婴危害大 ,特别是对胎儿 ,早产、胎儿宫内窘迫、围产儿病死率高是ICP的主要危害。Objective:To investigate the effect of the level of serum total bile acids(TBA) on patients with intrahepatic cholestasis of pregnancy(ICP) and their fetus.Methods:26 pregnant women with ICP and 40 controls were studied. Patients with ICP were divided into two groups: light ICP (15 μmol·L -1 <TBA≤50 μmol·L -1)and severe ICP ( TBA>50 μmol·L -1).Results:The gestational age at delivery , mode of delivery, incidence of meconium staining in the amniotic fluid, birth weight and postpartum hemorrhage were significantly different among the three groups(P<0.05).There were no significant differences in Apgar scores in all three groups .Conclusion:ICP can harm mother and fetus, especially to the fetus. Premature delivery, fetal distress, stillbirth and higher rate of neonatal death are the main harm of ICP. TBA is very useful in predicting the perinatal outcome of patients with ICP.

关 键 词：妊娠并发症 肝内胆汁淤积综合征 预后 血清 总胆汁酸 胎儿 

分 类 号：R714.255[医药卫生—妇产科学]