(S)-(+)-2-氨基丙醇的KBH_4还原合成法  

Preparation of (S)-(+)-2-Amino-1-propanol by KBH 4 Reduction

作　　者：杨运旭[1] 敬永生[2] 

机构地区：[1]河南职工医学院,河南郑州450003 [2]河南大学药学院,河南开封475001

出　　处：《中国医药工业杂志》2003年第2期65-66,共2页Chinese Journal of Pharmaceuticals

摘　　要：S)-(+)-2-Amino-1-propanol, the key chiral intermediate of levofloxacin, was preparation from L-2-aminopropionic acid by methyl esterification, and then direct reduction by KBH 4 without purification with an overall yield of 70%.S)-(+)-2-Amino-1-propanol, the key chiral intermediate of levofloxacin, was preparation from L-2-aminopropionic acid by methyl esterification, and then direct reduction by KBH 4 without purification with an overall yield of 70%.

关 键 词：氨基丙醇 KBH4 还原 合成法 左氟沙星 中间体 

分 类 号：TQ463.23[化学工程—制药化工]