单诺沙星在蛋雏鸡体内的药物动力学及生物利用度的研究  

Studies on pharmacokinetics and bioavailability of danofloxacin in chickens

作　　者：刘芳萍[1] 佟恒敏[1] 李昌文[2] 

机构地区：[1]东北农业大学动物医学院药理教研室,黑龙江哈尔滨150030 [2]中国农业科学院哈尔滨兽医研究所,黑龙江哈尔滨150001

出　　处：《中国兽医杂志》2003年第1期44-46,共3页Chinese Journal of Veterinary Medicine

摘　　要：选用 4～ 5周龄健康蛋雏鸡 12 5只 ,按 5 mg/kg的剂量进行静脉注射和内服单诺沙星的药动学研究及生物利用研究。高效液相色谱内标法测定血浆中药物浓度 ,MCPKP药动学程序处理药时数据。静脉注射和内服给药后血药浓度—时间数据分别符合无吸收因素二室开放式模型和一级吸收一室开放式模型。静脉注射给药的主要药动学参数为 :t1 /2α=0 .3313h、t1 /2β= 5 .994 0 h、Vd=7.5 2 4 6 L/kg、AU C=5 .6 916 μg/m l· h、CLB=0 .8935 L/kg· h。内服给药后主要药动学参数为 :t1 /2 Ka=0 .30 2 9h、t1 /2 K=6 .5 12 8h、tmax=1.2 10 0 h、Cmax=0 .5 15 9μg/m l、AU C=5 .132 9μg/ml· h。生物利用度为 90 .18%。The pharmacokinetic characteristics and bioavailability of danofloxacin following intravenous and oral administration were investigated in 125 healthy chickens by using the (High performance liquid chromatography, HPLC) interal method. The data were analyzed with the pharmacokinetic computer program MCPKP. The pharmacokinetic characteristics in the chickens following single intravenous and oral administration (5mg/kg) were best described by two compartment open model and one compartment open model with first order absorption, respectively. The main pharmacokinetic parameters intravenously were as follows: t 1/2α =0.3313 h?t 1/2β =5.9940 h?V d=7.5246 L/kg?AUC=5.6916 (μg/ml)·h?CL B= 0.8935 L/mg·h. The primary pharmacokinetic parameters of oral administration were showen below: t 1/2Ka =0.3029 h?t 1/2K =6.5128 h?t max =1.2100 h?C max =0.5159 μg/ml?AUC=5.1329 (μg/ml)·h. The bioavailability was 90.18%.

关 键 词：单诺沙星 蛋雏鸡 药物动力学 生物利用度 剂量 

分 类 号：S859.796[农业科学—临床兽医学]