潘生丁负荷时间-速度积分在急性心肌缺血研究中的意义  

Significance of Time Velocity Integral Combined with Dipyridamole Stress Echocardiography on Studies of Acute Myocardial Ischemia

作　　者：孙晖[1] 张军[1] 钱蕴秋[1] 李军[1] 贺建国[1] 张海滨[1] 姚志勇[1] 

机构地区：[1]解放军第四军医大学西京医院超声科,西安市710032

出　　处：《中国超声医学杂志》2003年第2期125-128,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的 :采用时间 -速度积分结合潘生丁负荷试验研究室壁运动异常与心肌缺血的关系并评价该技术在检测心肌缺血中的价值。方法 :7只开胸犬以冠状动脉缩窄器造成左旋支不同程度的狭窄 ,进行潘生丁负荷试验 :首剂量为 0 .5 6mg/ kg,4分钟后追加 0 .2 8mg/ kg。对心尖四腔、心尖两腔、心尖左室长轴等切面进行观察和分析。结果 :基础状态下 ,各长轴切面显示位由心底向心尖逐渐递减。当 L CX血流量减低 2 5 %并加用大剂量潘生丁负荷时 ,上述递减趋势被破坏 ,相应供血区位移幅度较基础状态显著减低 (P<0 .0 5 )。结论 :时间 -速度积分结合潘生丁负荷试验可以根据位移减低发现心肌缺血所致的局部室壁运动异常 。Objective:To investigate the relationship between myocardial ischemia and abnormal motions of left ventricular wall using time velocity integral combined with dipyridamole stress echocardiography and evaluate the significance of the new technology in detecting myocardial ischemia.Methods:Several grades of constriction on left circumflex coronary artery(LCX)were produced in seven open chest canine models.Dipyridamole was added in two steps,first 0 56mg/kg,then 0 28mg/kg after four minutes.Apical four chamber,two chamber and left ventrciualr long axis views were observed and analyzed.Results:In basal conditions,the displacement was progressively decreased from cardiac base to apex on each view of long axis.When the flow of LCX was decreased 25%,then the large dosage of dipyridamole was added,the tendency of decreasing was destroyed and the displacement of the corresponding blood supply area was decreased sharply compared with that of the basal conditions( P <0 05).Conclusions:According to the decreased displacement,time velocity integral combined with dipyridamole stress test can detect the local motion disorders of the ventricular wall caused by myocardial ischemia;thus,this method can supply a new way to the diagnosis of coronary heart disease.

关 键 词：潘生丁负荷试验 时间-速度积分 急性心肌缺血 检测 

分 类 号：R540.45[医药卫生—心血管疾病]