硫酸阿米卡星基-羟丙基-β-环糊精的合成研究  

Preparation of Amikacin Sulfate-Functionalized Hydroxypropyl-β-Cyclodextrin

作　　者：张纪贵[1] 刘玉法[1] 郝爱友[1] 

机构地区：[1]山东大学化学与化工学院,山东济南250100

出　　处：《化学世界》2003年第2期88-90,共3页Chemical World

摘　　要：将药物分子直接键连到环糊精分子上 ,可使药物分子具有良好的靶向施药性、抗过敏性。以高锰酸钾为氧化剂先将单 6-羟丙基 - β-环糊精选择性氧化得到单 6-丙酮基 - β-环糊精 ,再利用羰基和氨基生成席夫碱键的反应 ,在酸性条件下 ( p H=4～ 5 )将硫酸阿米卡星直接键连到单 6-丙酮基 -β-环糊精上 ,制得了水溶性硫酸阿米卡星基 -羟丙基 - β-环糊精。The medicinal molecules can be bound to cyclodextrins(CDs) directly, and the compounds resulted may display features of control releasing and allergic resistance. Amikacin sulfate modified hydroxypropyl β CD was prepared by reaction of amikacin sulfate with the single 6 acetonyl β CD, which was obtained by oxidation of the single 6 hydroxypropyl β CD. The compounds obtained were analysed by both 1H and 13 C NMR spectroscopy, and the effect of reaction conditions were also studied.

关 键 词：硫酸阿米卡星基-羟丙基-β-环糊精 硫酸阿米卡星 合成 药物分子 靶向施药性 药物控制释放 

分 类 号：R944.9[医药卫生—药剂学]