江苏省肠道线虫病不同流行区集体化疗效果的研究  

EVALUATION ON EFFICACY OF MASS CHEMOTHERAPY AGAINST INTESTINAL NEMATODIASIS IN DIFFERENT ENDEMIC AREAS OF JIANGSU PROVINCE

作　　者：曹汉钧[1] 孙凤华[1] 钱益新[1] 徐振刚[1] 赵兰凤[1] 陈锦英[1] 葛均 高佳方 杨昌林 刘浩坤[5] 

机构地区：[1]江苏省寄生虫病防治研究所,无锡214064 [2]江苏省卫生厅 [3]江苏省武进市血吸虫病防治站 [4]江苏省东台市卫生防疫站 [5]江苏省赣榆县卫生防疫站

出　　处：《中国血吸虫病防治杂志》2003年第1期57-60,共4页Chinese Journal of Schistosomiasis Control

摘　　要：目的　探索肠道线虫病不同流行区的集体化疗方案 ,为指导防治工作提供决策依据。方法　选择江苏省不同状况的 3个村 ,分别采用每年 1次或 2次集体化疗并连续 3年 ;对人群肠道线虫感染和土壤中虫卵、钩虫幼虫污染情况进行观察研究。结果　苏南试点村连续 3年每年 1次集体化疗后 ,肠道线虫总感染率从 32 .33%降至 2 .0 8% ;钩、蛔、鞭虫的单虫感染率比防治前分别下降94 .4 7%、 86 .6 0 %、92 .6 2 %。苏中和苏北试点村经过 3年 6次集体化疗 ,总感染率由防治前的86 .80 %和 88.76 %下降至 5 .11%和 7.98% ;单虫感染率均比化疗前下降 90 %以上 ,苏北试点村钩虫感染率降至 0。感染度、多重感染和土壤中虫卵、钩虫幼虫污染情况与感染率同步下降。结论　在肠道线虫病不同流行区应采用不同的集体化疗方案 ,以保证防治效果 ,避免盲目用药 ;对感染率30 %左右的地区 ,每年 1次集体化疗连续 2 - 3年即可降至 5 %以下 ,在感染率高达 80 %以上的地区 ,每年 2次 ,连续 2 - 3年亦可将感染率降至 10 %以下。Objective To explore the mass chemotherapy schemes against intestinal nematodiasis in different endemic areas so as to provide scientific basis for decision making to control the diseases. Methods Three villages according to the different geographical, economic and epidemic situations were selected in Jiangsu Province. Each was treated with mass chemotherapy, once per year or twice per year respectively. sustained 3 years. Infection in population as well as contaminations of egg and hookworm larvae in soil were observed and the different chemotherapy schemes were evaluated. Results After 3 years' continual mass chemotherapy of once per year in pilot experimental village in the Southern Jiangsu, overall infection rate of intestinal nematodes dropped from 32.33% to 2.08%; infection rates of Ancylostoma, Ascaris and Trichuris dropped by 94.47%, 86.60%, 92.62%. respectirely. After 3 years and 6 times' mass chemotherapy in the Middle and Northern Jiangsu , overall infection rates decreased from 86.8% and 88.78% to 5.11% and 7.98% respectively; individual infection rates decreased by more than 90%. Especially, the infection rate of Ancylostoma in the North Jiangsu pilot village dropped to zero. The intensity of infection, multiple infection and contaminations of egg and hookworm larvae all decreased at the same time. Conclusion Different mass chemotherapy schemes should be carried out in different endemic areas to guarantee the efficacy as well as to avoid the abuse of medicine. For areas with a prevalence being about 30%, 2-3 years continuous mass chemotherapy of once per year the prevalence will decrease to be less than 5%, while for those with a prevalence being more than 80%, 2-3 years continuous mass chemotherapy of twice per year the prevalence will also decrease to be less than 10%.

关 键 词：肠道线虫 集体化疗 防治效果 江苏 

分 类 号：R532.21[医药卫生—内科学]