霍乱弧菌的致病性与流行性研究进展  

Advance of Vibrio cholerae Study on Pathogenicity and Pandemicity

作　　者：王洪敏[1] 马文丽[1] 郑文岭[2] 

机构地区：[1]第一军医大学分子生物学研究所,广州510515 [2]广州军区广州总医院

出　　处：《生物化学与生物物理进展》2003年第1期38-42,共5页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目 ( 39880 0 32 );广州市重点科技公关项目 ( 990 4480 2 2 ) .~~

摘　　要：综述了近年来霍乱弧菌的致病性和流行性的研究进展 ,并讨论了流行性和致病性的关系 .编码霍乱毒素CT的基因ctxAB并不是霍乱弧菌基因组自身的成分 ,而是CTXΦ噬菌体基因组的一部分 .CTXΦ能特异性地感染并整合至霍乱弧菌的基因组 ,成为CTX原噬菌体 ;携带有CTX原噬菌体的霍乱弧菌在环境因素的诱导下 ,也能向外界分泌CTXΦ噬菌体 .RS1基因元件与CTX基因元件在染色体位置上紧邻 ,它们在功能上也紧密相关 ,RS1元件能利用CTXΦ的基因形成一个丝状噬菌体RS1Φ ,并能向细胞外分泌 ,进行水平传播 ;VPI来源于VPIΦ ,VPIΦ能在霍乱弧菌的菌株之间传播 ;VPI是霍乱弧菌获得CTX基因元件的桥梁 .最近 ,又发现了两个与霍乱大流行相关的两个基因区域 ,VSP Ⅰ和VSP Ⅱ .The advances of research on the pathogenicity and pandemicity of Vibrio cholerae in recent years are reviewed. The gene ctxAB encoding cholera toxin CT is not a native component of Vibrio cholerae genome, while it originally comes from a bacteriophage CTXPhi. CTXPhi can specifically infect Vibrio cholerae and integrate into its genome, forming a prophage; while it can also secrete CTXPhi under the induction of the environmental factors. RS1 and CTX gene elements not only closely located in chromosome position, but also closely related functionally. RS1 element can also transform into a filamentous phage RS1Phi, secrete and transfer horizontally. VPI comes from VPIPhi, which can transmit between Vibrio cholerae strains, and it is the bridge for Vibrio cholerae to acquire CTX gene element. Two gene regions VSP-I and VSP-II closely related to pandemicity of the Vibrio cholerae were identified recently. The relationship between pathogenicity and pandemicity is discussed.

关 键 词：霍乱弧菌 致病性 流行性 研究进展 

分 类 号：R378.3[医药卫生—病原生物学] R516.5[医药卫生—基础医学]