肺炎双球菌肺炎老龄大鼠自由基和前列腺素代谢变化  

Changes of free radical and prostaglandin metabolismin the aged rats with pneumococcus pneumonia

作　　者：李建生[1] 杨戈[1] 李贻奎[1] 郭胜典[1] 

机构地区：[1]河南中医学院老年医学研究所,河南郑州450003

出　　处：《中国老年学杂志》2003年第4期249-251,共3页Chinese Journal of Gerontology

基　　金：河南省高校创新人才基金 (2 0 0 0 - 1 0 )资助

摘　　要：目的　从自由基和前列腺素代谢研究老年肺炎的病理生理特点。方法　复制肺炎双球菌肺炎模型 ,分为青年对照组和模型组 ,老龄对照组和模型组。观察肺脏组织病理改变 ,外周血前列腺素代谢产物 ,肺泡灌洗液中性粒细胞计数、SOD活性、NO和 MDA含量。结果　肺炎的肺组织损伤老龄大鼠较青年大鼠严重。青年模型组和老龄模型组肺泡灌洗液中性粒细胞、血浆 TXB2 含量的增高和血浆 6- Keto- PGF1α含量的降低均分别较青年对照组和老龄对照组显著。青年模型组和老龄模型组血清和肺泡灌洗液 SOD活性降低、NO、MDA含量增高 ,分别较青年对照组和老龄对照组显著。与青年对照组比较 ,老龄对照组血清和肺泡灌洗液 SOD活性减低和 MDA含量升高。与青年模型组比较 ,老龄模型组血清和肺泡灌洗液MDA和肺泡灌洗液 NO含量增高。结论　中性粒细胞和前列腺素及自由基介导的损伤参与肺炎的发生发展。Objective To study the physiopathological character of pneumonia in the aged from the changes of free radical (FR) and prostaglandin (PG). Methods Duplicated the model of rats with pneumococcus pneumonia and divided the rats into young control group (YCG), young model group (YMG), aged control group (ACG) and aged model group (AMG). The pathological change of lung tissue, the level of blood PG, and the count of neutrophil, Nitride oxide (NO), Malandialdehyde (MDA),the activity of Super oxide demutase (SOD) in Bronchoalveolar lavage fluid (BALF) were measured. Results The lung tissue injury in AMG was more serious than that in the YMG. The increase of level of BALF neutrophil and blood TXB2 and the decrease of blood 6-Keto-PGF1αin YMG and AMG was obvious respectively than those in YCG and ACG. The level of blood and BALF SOD was lower and level of NO and MDA was higher respectively in YMG and AMG than those in YCG and ACG. Compared with that in the YCG, the activity of SOD decreased and the content of MDA increased in BALF and serum in the YMG. Compared with that in YMG, the level of serum SOD decreased,the content of in BALF and serum MDA and BALF NO increased in AMG. Conclusions The neutrophil, PG metabolism and injury of FR were concerned with the pathological development in the rats with pneumonia. The injury of FR in aged rats was more obvious than that in young rats.

关 键 词：肺炎 老年人 双球菌肺炎 自由基 中药 复方毒素清 前列腺素代谢 

分 类 号：R563.1[医药卫生—呼吸系统]