广西藤茶总黄酮的长期毒性试验  

The Rat Chronic Toxicity Test of Total Flavone of Ampelopsis grossedentata from Guangxi

作　　者：钟正贤[1] 周桂芬[1] 陈学芬[1] 覃洁萍[2] 

机构地区：[1]广西中医药研究所,广西南宁530022 [2]广西中医学院,广西南宁530006

出　　处：《时珍国医国药》2003年第4期193-195,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家中医药管理局中医药科学技术研究基金资助项目〔国中医药科 0 0 - 0 1 L(M)〕;广西青年科学基金资助项目(桂科青 0 0 0 70 2 5)

摘　　要：目的 :观察广西藤茶总黄酮对大鼠长期毒性试验的影响。方法 :广西藤茶总黄酮以 1.5 g/ kg和 0 .3g/ kg(为临床日用量的 5 0倍和 10倍 )剂量给大鼠连续灌服 12周 ,停药 2周 ,分别测量大鼠体重 ,计算脏器系数 ,测定血液学和血液生化学指标 ,并作组织病理学检查。结果 :广西藤茶总黄酮大小剂量组动物的外观行为 ,体重 ,脏器系数 ,血液学和生化学指标 ,与空白对照组比较 ,均无明显差异 ;病理检查未见与药物毒性相关的明显病变 ,停药后也未见药物延迟性毒性反应。结论 :广西藤茶总黄酮长期用药对大鼠无明显毒性 。Objective:To observe the effects of total flavone of Ampelopsis Grossedentata from Guangxi(GXTF) on the rat chronic toxicity test.Methods:The rats were orally given for 12 weeks with the doses of 1.5g/kg and 0.3g/kg (being 50 and 10 times of clinic dose ) and for 2 weeks of stopping adiministration, the rat weights, organ coefficients, the indexes of hemotology and biochemistry were determined , and the pathological examination were carried out.Results: The outer appearance and behavior, weights, organ coefficients, the indexes of hemotology and biochemistry in rats has no significant difference by comparing with control group; the pathological examination was not discovered significant pathological changes with relation of drug toxicity and the delayed toxicity reaction in stopping adiministration later. Conclusion: The GXTF has no significant toxicity for long-term adiministration in rats, and infers that the drawing up doses in clinic will be safe.

关 键 词：广西藤茶 总黄酮 长期毒性试验 血液学 血液生化学 组织病理学 

分 类 号：R285.5[医药卫生—中药学]