3,6-二氯水杨酸的合成研究  

Study on the Synthesis of 3,6-Dichloro-salicylic Acid

作　　者：严招春 

机构地区：[1]浙江水晶电子集团公司医化部,浙江台州318000

出　　处：《化工生产与技术》2003年第2期8-9,共2页Chemical Production and Technology

摘　　要：在二甲苯溶剂中,2,5-二氯苯酚与氢氧化钾共沸脱水后成盐,酚盐与CO2进行高压羧基化反应制得3,6-二氯水杨酸,最高收率达78.7%,HPLC含量≥99.4%。A solution of 2,5-dichlorophenol in xylene is azeotropic distilled with potassium hydroxide until no more water is separated. The obtained anhydrous potassium 2,5-dichlorophenolate solution is carboxylated with CO2 under elevated pressure to form 3,6-dichloro-salicylic acid with a yield of 78.7% and a HPLC purity of more than 99.4%.

关 键 词：3 6-二氯水杨酸 合成 研究 二甲苯溶剂 2 5-二氯苯酚 氢氧化钾 高压羧基化反应 

分 类 号：TQ242[化学工程—有机化工]