RP-HPLC测定格列美脲胶囊的溶出度  

Determination of dissolubility from Glimepiride capsules by RP-HPLC

作　　者：杨蕾[1] 黄瑛[1] 谢华[1] 刘仲义[1] 周益芬 

机构地区：[1]四川省药品检验所,四川,成都,610036

出　　处：《华西药学杂志》2003年第2期137-139,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的　采用反相高效液相色谱法测定格列美脲胶囊的溶出度。方法　选用ODS柱 ,流动相为甲醇 -磷酸二氢铵溶液(8∶3) ,检测波长 2 2 8nm。结果　格列美脲在 0 .0 4 11～ 3.0 84 μg范围内呈良好的线性关系 (r=0 .999) ,平均回收率 10 1.1% ,RSD =1.5 3%。结论　该方法操作简单 ,准确快速 ,可用于格列美脲胶囊的溶出度测定。OBJECTIVE An RP-HPLC method was used for determining glimepiride dissolution from Glimepiride capsules.METHODS An ODS column,Methanol-Ammonium dihydrogen phosphate(8∶3)were used.The detection wavelength was 228 nm.RESULTS The calibration curves showed good linearity over the range of 0.0411-3.084 μg( r =0.9999) The average recovery was 101.1% with RSD = 1.53% .CONCLUSION The method was simple,accurate and rapid.

关 键 词：格列美脲胶囊 降血糖药 溶出度 反相高效液相色谱法 

分 类 号：R977.15[医药卫生—药品] R917[医药卫生—药学]