新生儿窒息后血清心肌肌钙蛋白I测定及临床意义  

The clinical significance of serum cardiac troponin I detection after asphyxia neonatorum.

作　　者：黄莉芬 张晓[2] 

机构地区：[1]武钢总医院儿科,湖北武汉430080 [2]武汉大学人民医院儿科

出　　处：《中国冶金工业医学杂志》2003年第2期83-85,共3页Chinese Medical Journal of Metallurgical industry

摘　　要：目的 :探讨新生儿窒息患儿血清心肌肌钙蛋白I(cTn -I)水平及临床意义。方法 :采用全自动化学免疫系统检测 4 0例新生儿窒息患儿 (轻度窒息、重度窒息 )血清cTn -I和肌酸磷酸激酶心型同功酶 (CK -MB) ,并与 10例健康新生儿进行对照比较。结果 :各组窒息新生儿血清cTn -I浓度明显升高 ,轻度窒息组、重度窒息组两两之间及与对照组相比均差异显著 (P <0 0 5)。窒息组血清中cTn -I浓度与CK -MB浓度呈显著正相关 (r=0 6 6 9,P <0 0 5)。窒息组中有心血管并发症与无心血管并发症患儿血清cTn -I浓度比较有显著差异 (P <0 0 5) ,且重度窒息组中两者差异更显著 (P <0 0 1)。轻度窒息组和重度窒息组中有心血管并发症组患儿血清cTn -I浓度比较差异显著 (P <0 0 5) ;而无心血管并发症组患儿血清cTn -I浓度相比无显著差异 (P >0 0 5)。结论 :cTnObjective:To investigate the clinical significance of serum cardiac troponin I(cTn-I)level after asphyxia neonatorum.Methods:The serum cTn-I and the CK-MB of 40 patients with asphyxia neonatorum(mild asphyxia\,severe asphyxia)were detected by full-automatic chemo-immune system,and were compared with 10 cases of health new-born.Results:The concentration of serum cTn-I in various asphyxia neonatorum groups increased obviously,the mild asphyxia group compared with the severe asphyxia group,and these two groups compared with the control group,there were significant difference among them(P<0.05).The concentration of serum cTn-I and the CK-MB in asphyxia group had notable positive correlation( r =0\^669,P<0.05).The concentration of serum cTn-I in asphyxia group with cardiovascular complication compared with the asphyxia group without cardiovascular complication,there were significant difference between them(P<0.05),and there were notable difference between them in severe asphyxia group(P<0.01).The concentration of serum cTn-I in severe asphyxia group with cardiovascular complication were higher than that in mild asphyxia group with cardiovascular complication,there were significant difference between them(P<0.05),but there were no difference between two groups without cardiovascular complication(P>0.05).Conclusions:The cTn-I might act as an auxiliary index to diagnose the acute myocardial damage suffering from asphyxia neonatorum.

关 键 词：新生儿 窒息 血清 心肌 肌钙蛋白Ⅰ 测定 

分 类 号：R722.1[医药卫生—儿科]