甲烷单加氧酶化学模拟研究进展  

Advances in mimic of methane monooxygenase

作　　者：寇兴明[1] 曾宪诚[1] 胡常伟[1] 

机构地区：[1]四川大学化学学院四川省绿色化学与技术重点实验室,四川成都610064

出　　处：《化学研究与应用》2003年第2期171-176,共6页Chemical Research and Application

基　　金：国家自然科学基金资助项目(20173038;20107004)

摘　　要：本文综述了近年来对甲烷单加氧酶进行结构模拟和催化功能模拟研究工作的进展情况。就结构模拟而言,已合成和表征了很多模型化合物,并与天然酶进行了比较,获得了一些能较好地再现天然酶活性中心结构特征和谱学特征的模型化合物。在催化功能模拟方面,少数体系能将环己烷等烃类转化为醇类或酮类。而真正能把甲烷转化成甲醇的体系仅有一例报道,这方面的工作比较薄弱,尚待加强。The advance in mimic of methane monooxygenase(MMO)in recent years was reviewed.Thus far a lot of work has been done in mimiching the structure of MMO.Many model complexes have been synthesized,characterized and compared with the natural enzyme.Some model complexes exhibit the similarities of structure and spectroscopy to the natural enzyme.In contrast to mimic of structure of MMO,less investigation on mimic of catalytic function has been carried out.Several model complexes can catalyze the conversion of cyclohexane into cyclohexanol and cyclohexanone.Only one example of catalytic conversion of methane to methanol has been reported.

关 键 词：甲烷单加氧酶 化学模拟 双核铁配合物 选择性氧化 甲醇 酶模型 活性中心 结构 

分 类 号：O623.11[理学—有机化学] Q554[理学—化学]