喹啉酮衍生物的合成及其心血管活性  

Synthesis and cardiovascular activities of 3-pheny1-4(1H)quinolinone halide derivatives

作　　者：王晓莉[1] 徐鸣夏[1] 李瑞雪[1] 蔡绍辉[2] 

机构地区：[1]四川大学华西医学院,四川成都610041 [2]四川大学华西药学院,四川成都610041

出　　处：《化学研究与应用》2003年第2期280-281,F003,共3页Chemical Research and Application

摘　　要：Isoflavonoids possess broad activities besides cardiovascular activity.3 phenyl 4(1H)quinolinone derivatives are isosteres of isoflavonoids.They have similar spatial structures.Eight 3 phenyl 4(1H)quinolinone halide derivatives were synthesised for studying their biological activities especially cardiovascular activity.Their chemical structures were confirmed by 1 H NMR,MS and IR.The preliminary tests with isolated heart of rabbits indicated that both mixtures,A 1B 1,A 2B 2,had more positive inotropic effect than vesnarinone which appeared on the market in Japanese.The results of the pharmacological tests showed that the two mixtures did not affect the blood pressure and respiration of the dogs.Isoflavonoids possess broad activities besides cardiovascular activity.3 phenyl 4(1H)quinolinone derivatives are isosteres of isoflavonoids.They have similar spatial structures.Eight 3 phenyl 4(1H)quinolinone halide derivatives were synthesised for studying their biological activities especially cardiovascular activity.Their chemical structures were confirmed by 1 H NMR,MS and IR.The preliminary tests with isolated heart of rabbits indicated that both mixtures,A 1B 1,A 2B 2,had more positive inotropic effect than vesnarinone which appeared on the market in Japanese.The results of the pharmacological tests showed that the two mixtures did not affect the blood pressure and respiration of the dogs.

关 键 词：喹啉酮衍生物 合成 心血管活性 3-苯基-4(1H)喹啉酮 抗菌药 抗菌活性 

分 类 号：TQ463.5[化学工程—制药化工] R978.1[医药卫生—药品]