2-烃基-2,2-二烯丙基乙酸类化合物的新法合成  

A Novel Method for Preparing 2-Alkyl-2,2-diallylacetic Acids

作　　者：邹小卫[1] 吕铁梅[1] 宋霁[1] 吴范宏[1] 沈永嘉[1] 

机构地区：[1]华东理工大学化学与制药学院,上海200237

出　　处：《华东理工大学学报（自然科学版）》2003年第2期210-213,共4页Journal of East China University of Science and Technology

基　　金：国家自然科学基金资助项目(29902001)

摘　　要：以2位烃基取代乙酸为起始原料,与烯丙基氯反应成酯后,在氢化钠的催化作用下进行Claisen重排反应得到4-戊烯酸类化合物,再经酯化和Claisen重排反应得到2-烃基-2,2-二烯丙基乙酸类化合物,4步反应收率为15.4%～53.5%。A novel and practical synthetic method for the preparation of 2alkyl2,2diallylacetic acids was reported. 2Alkyl4pentenioc acids was obtained by esterification of 2alkylacetic acids with allyl chloride and Claisen rearrangement catalyzed by sodium hydride. After esterification and Claisen rearrangement of 2alkyl4pentenioc acids, 2alkyl2,2diallylacetic acids was obtained in 15.4%～53.5% yield.

关 键 词：2—烃基—2 2—二烯丙基乙酸类化合物 4—戊烯酸 C1aisen重排反应 合成方法 药物中间体 

分 类 号：TQ463.25[化学工程—制药化工]