充血性心衰患者血浆内皮素,降钙素基因相关肽和神经肽的变化  

Plasma endothelin,calcitonin gene relative peptide and neuropeptide Y in patients with congestive heart failure

作　　者：辛渭川[1] 冯关力[1] 白引珠[1] 

机构地区：[1]西安市中心医院心血管内科,陕西西安710003

出　　处：《第四军医大学学报》2003年第6期529-531,共3页Journal of the Fourth Military Medical University

摘　　要：目的 :研究充血性心衰患者治疗前后内皮素 (ET)、降钙素基因相关肽 (CGRP)、神经肽Y(NPY)的变化 .方法 :充血性心衰患者 4 2 (男 3 1,女 11)例 ,年龄 (47± 12 )岁 ,包括肺心病 10例、风心病 19例 ,扩张型心肌病 13例 ;心功能NYHAⅡ级 14例 ,Ⅲ级 2 3例和Ⅳ级 5例 ,应用常规抗心衰等治疗 .无心血管疾病的对照 2 2 (男 16,女 6)例 ,年龄 (45± 10 )岁 .入院后次日和治疗 4wk后晨 0 7 0 0空腹采肘正中静脉血标本 3mL ,用放射免疫测定方法测定血浆中血浆ET ,CGRP和NPY含量 .结果 :经过内科常规治疗 4wk后 ,4 2例患者均有效 ,心功能NYHAⅠ级 9例 ,Ⅱ级 2 8例 ,Ⅲ级 4例和Ⅳ级 1例 .患者治疗后ET(112± 2 8vs 74± 15 ,P<0 .0 1) ,CGRP(89± 2 9vs 67± 18,P <0 .0 1)和NPY(186± 19vs13 9± 17,P <0 .0 1)含量 (μg·L-1)明显下降 ,与对照比较无明显差异 (P >0 .0 5 ) ,且ET ,CGRP和NPY三者均明显相关 (r =0 .4 3 6～ 0 .4 5 6,P <0 .0 5 ) .结论 :血浆ET、CGRP)和NPY含量在充血性心衰明显升高 ,治疗好转后可恢复正常 。AIM:To study the changes of plasma endothelin (ET),calcitonin gene relative peptide (CGRP) and neuropeptide Y (NPY) in patients with congestive heart failure and their clinical significance. METHODS: There were 42 patients (male 31,female 11, age 47±12 years old) with congestive heart failure including cor pulmonale(n=10),rheumatic heart disease(n=19) and dilated cardiomyopathy(n=13), and cardiac function (NYHA grade) consisted of Ⅱ(n=14), Ⅲ(n=23) and Ⅳgrade (n=5). With routine therapy for the patients, plasma levels of ET, CGRP, NPY were determinated by radioimmunossay kit at fasting 07:00 AM in second hospitalization day and 4 weeks after therapy.RESULTS: After internal medical therapy for 4 weeks, there were effects and cardiac function improvment toⅠ(n=9),Ⅱ(n=28),Ⅲ(n=4) and Ⅳgrade (n=1); and in contrast with pre therapy, plasma (μg·L -1 )ET( 112±28 vs 74±15,P<0 01),CGRP(89±29 vs 67±18,P<0.01) and NPY(186±19 vs 139±17,P<0.01)were obviously lowered, and plasma ET level correlated with CGRP or NPY significantly(r=0.436～0.456,P<0.05); and unchanged than that control(P>0.05).CONCLUSION: After internal medical therapy for patients with congestive heart failure can be improved the contents of plasma ET, CGRP and NPY.

关 键 词：心力衰竭 充血性 内皮缩血管肽类 降钙素基因相关肽 神经肽Y 

分 类 号：R541.61[医药卫生—心血管疾病]