不同类型苷类在大孔吸附树脂上的吸附纯化特性研究  

The Study of Characteristics of Absorption and Separation of Different Glycoside on Macropore Resins

作　　者：毕岳琦[1] 侯世祥[1] 毛声俊[1] 熊迎新[1] 

机构地区：[1]四川大学华西药学院中药制剂研究室,四川成都610041

出　　处：《中国中药杂志》2003年第3期217-220,共4页China Journal of Chinese Materia Medica

摘　　要：目的 :研究黄芩苷等 3种具有不同类型母核的苷类中药成分在大孔吸附树脂上的吸附纯化特性。方法 :以黄芩、栀子和白芍为样本考察它们在D10 1等 6种不同树脂上的吸附纯化特性。结果 :6种非极性树脂对 3种苷类总体静态吸附能力为黄芩苷 >芍药苷 >栀子苷 ,其洗脱溶剂分别为 75 % ,2 5 % ,4 5 %的乙醇 ,洗脱率分别为6 0 % ,93% ,93%。结论 :具有相似母核结构的苷类分子在同一树脂上吸附能力不一定相似 ,但吸附力的大小与分子结构有关 ,对苯乙烯型树脂而言 ,被吸附的分子母核双键数目越多 。Objective: To study the absorption and separation of different glycoside on different macropore resins.Method: Take baikal skullcap root, cape jasmine fruit and white peony root as samples and study the different characterstics of absorption and separation of these samples on macropore resins such as D101 and so on. Result: The static absorption effect of the the three aglycones on six different macropore resins is baicalin> lactiflorin> gardoside.Their elution are 75% CH 3OH, 25% CH 3OH, and 45% CH 3OH.Their elution rates are 60%, 93%, and 93%. Conclusion: Similar molecules may not have similiar absorption abilities on same macropore resins, but the effect of absorption has something to do with the structures of the molecules, the more double bonds the molecules have, the greater the absorption force the resins have.

关 键 词：苷类 大孔吸附树脂 吸附纯化特性 

分 类 号：TQ461[化学工程—制药化工]