丹参素在加温加速条件下的含量变化规律研究  

Studies on Variation of Danshensu Content in Accelerated Stability Tests

作　　者：毛声俊[1] 侯世祥[1] 唐昌炯[1] 黄晓东[1] 

机构地区：[1]四川大学华西药学院中药制剂研究室,四川成都610041

出　　处：《中国中药杂志》2003年第3期220-222,共3页China Journal of Chinese Materia Medica

摘　　要：目的 :探讨加温加速条件下丹参素在其对照品及丹参注射液中的含量变化规律 ,为丹参素的稳定性研究提供参考资料。方法 :采用HPLC法测定丹参素含量 ,经典恒温加速试验法考察丹参素在对照品溶液与丹参注射液中的含量变化。结果 :在加温加速试验条件下 ,对照品中的丹参素含量降低 ;而注射液中的丹参素含量反而增高。结论 :丹酚酸类化合物在加速试验条件下能水解生成丹参素 ,含丹参制剂在以丹参素为指标预测及评价其稳定性时 。Objective: To study the variation Laws of content of danshensu accelerated in control and in danshen injection in order to provide reference for stability investigation of danshensu. Method:The tests was carried out by classic isothermal method and the content of danshensu was determined by HPLC.Result: The contents of danshensu in accelerated tests increase in control and decrease in danshen injection respectively.Conclusion: The component of phenic acidity would be hydrolyzed to become danshensu in the accelerated tests. Much attention should be paid to the unusual increase when studies of danshen preparations are carried out.

关 键 词：丹参素 酚酸 加速试验 稳定性 含量变化规律 

分 类 号：R286[医药卫生—中药学]