参附注射液对心肌缺血犬血流动力学和对动物血压的影响  

The Influence on Hemodynamecs of Myocardial Ischemic Dogs and Blood Pressure of Animals With Shenfu Injection

作　　者：杨芳炬[1] 王正荣[1] 林代平[1] 屈艺[1] 尹华虎[1] 史立丽[1] 郭惠玲[1] 肖静[1] 王跃奇[1] 刘荣韬[1] 

机构地区：[1]四川大学华西基础医学与法医学院,四川成都610041

出　　处：《中国中药杂志》2003年第3期259-262,共4页China Journal of Chinese Materia Medica

摘　　要：目的 :观察参附注射液对心肌缺血犬血流动力学和对犬、大鼠血压的影响。方法 :结扎犬左冠状动脉前降支造成心肌缺血及低血压 ;缩窄大鼠腹主动脉造成血管阻力增加而形成继发性高血压 ;分别给予参附注射液5 ,10mL·kg-1,观察其对犬血流动力学和对动物正常血压或高血压的影响。结果与结论 :参附注射液使心肌缺血犬的心脏做功能力显著提高 ,在不明显增加心肌耗氧量情况下使心收缩力增强 ,心输出量增加 ;并使心肌缺血所致的血压降低出现明显的回升作用 ;而对继发性高血压和正常动物血压无明显影响。Objective:To investigate the influence of Shenfu injection on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of dogs and rats. Method:Myocardial ischemic model was made and hypotension in the dogs was induced with ligating left front descending limb coronary artery method, and secondary hypertension by narrowing nephridium artery of rats, Shenfu injection was administered with 5, 10mL·kg -1 to the above dogs and rats separately to investigate the influence of it on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of rats. Result and Conclusion:Shenfu injection enhanced the capacity of myocardial work markedly; it augmented the myocardium contractility and cardiac output without raising the oxygen consume, and at the same time it returned normal the blood pressure in myocardial ischemic; but it had no effects on the normal blood pressure and secondary hypertension of rats.

关 键 词：参附注射液 心肌缺血 心功能 血流动力学 继发性高血压 

分 类 号：R285.5[医药卫生—中药学]