异丙肌苷及其主要成分抗多房棘球蚴作用的体外研究  

In vitro Effects of Isoprinosine and Its Main Component on Alveolar Hydatid Cyst

作　　者：王昕[1] 薛弘燮[1] 阿孜古丽.吐尔逊 温浩[2] 

机构地区：[1]新疆医科大学病原学教研室,新疆乌鲁木齐830054 [2]新疆医科大学包虫病临床研究室,新疆乌鲁木齐830054

出　　处：《地方病通报》2003年第1期25-27,100,101,共5页Endemic Diseases Bulletin

摘　　要：为研究异丙肌苷和其主要成分肌苷在体外抗多房棘球蚴和原头节的效果 ,运用 RPMI16 4 0作培养基体外培养原头节 ,后加入异丙肌苷或肌苷 ,使培养基中的药物浓度分别为 1m M,2 m M,4 m M,连续培养 9d,结果没有发现异丙肌苷和肌苷对多房棘球蚴的原头节和小囊有杀灭作用 。Protoscoleces/vesicles cultivation in vitro was used to evaluate the effect of isoprinosine and its main component inosine against protoscoleces/vesicles of Echinococcus multilocularis metacestodes. Isoprinosine and inosine were dissolved in RPMI 1640. Concentration was 1mM, 2mM, 4mM respectively. The cultivation was maintained 9 days. As a result, we didn't find that isoprinosine and inosine had efficacy on protoscoleces/vesicles in vitro. So it was still a question for study about whether isoprinosine had direct action against Echinococcus multilocularis metacestodes.

关 键 词：多房棘球蚴 异丙肌苷 药物治疗 体外实验 

分 类 号：R383－33[医药卫生—医学寄生虫学] R453[医药卫生—基础医学]