糖尿宁对糖尿病大鼠ET-1、GMP-140与TXB_2等的影响  

Effects of Tang Niao Ning Decoction on ET-1, GMP-140 and TXB_2 in Diabetic Rats

作　　者：宋菊敏[1] 王丽芬[1] 廖菡[1] 王伟[1] 华卫国[1] 

机构地区：[1]上海中医药大学基础医学院中医基础学科中心实验室,上海200032

出　　处：《标记免疫分析与临床》2003年第1期22-25,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：为了研究糖尿宁复方对高糖高脂糖尿病大鼠的降糖、降脂作用及对内皮素 - 1(ET - 1)、血小板α -颗粒膜蛋白 (GMP - 14 0 )、血浆血栓素B2 (TXB2 )和 6 -酮 -前列腺素F1α(6 -Keto -PGF1α)的影响 ,采用雌性Wistar大鼠 ,尾静脉注射小剂量链脲霉素 (STZ) ,喂以高脂饲料 ,随机分成糖尿宁组与模型组 ,同时设正常组。高脂饲料喂养一周后 ,糖尿宁组开始用药 ,用药六周后处死动物 ,检测以上指标。结果显示 :模拟的高糖高脂糖尿病大鼠经糖尿宁治疗后 ,发现该复方能降低血糖、血脂、ET - 1、GMP - 14 0、TXB2 及升高 6 -keto -PGF1α。同时也表明 :糖尿宁具有整体调节的特点 ,能改善患者的总体状况 ,可以平衡糖脂代谢紊乱及明显改善血液的高凝状态 。To investigate the effects of Tang Niao Ning decoction on fasting blood glucose (FBG), total cholesterol (TC), triglycerode (TG), endothelin (ET-1), platelet granule membrane protein (GMP-140), thromboxane B 2 (TXB 2), 6-keto-prostaglandin F 1α (6-keto-PGF 1α ), the selected female Wistar rats were modeled by streptozotocin (STZ) and high fat diets, and were randomly divided into two groups as Tang Niao Ning and model group, while the normal control group was set up. The Tang Niao Ning group started to supply decoctions after these rats had been fed one week with high fat diets. The rats were killed after six weeks. Above items were examed. The results showed that the model group displayed marked difference when the experiment finished compared with the normal group. The contents of fasting blood glucose and blood lipid were increased, accompanied with the phenomena of hoisting ET-1, enhancing GMP-140, increasing TXB 2 and droping 6-Keto-PGF 1α . After treatment in time with Tang Niao Ning decoction, all kinds of items were adjusted to normal level gradually. It suggested that the treatment with Tang Niao Ning decoction might decrease FBG and blood lipid. In some ways, the decoction could improve the signs of blood stasis. The regulation mechanisms of the decoction was characteristic of wholism through many channels.

关 键 词：糖尿宁 糖尿病 大鼠 ET-1 GMP-140 TXB2 影响 内皮素 血小板Α-颗粒膜蛋白 6-KETO-PGF1Α 

分 类 号：R285.5[医药卫生—中药学]