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机构地区:[1]成都中医药大学药学院中药材标准化教育部重点实验室四川省中药资源系统研究与开发利用重点实验室-省部共建国家重点实验室培育基地,四川成都611137 [2]成都大学基础医学与护理学院,四川成都610106 [3]茂县羌医药研究所,四川茂县623200
出 处:《中药与临床》2015年第5期33-35,共3页Pharmacy and Clinics of Chinese Materia Medica
基 金:四川省教育厅项目(14ZA0073);四川省科技厅项目(2011SZ0063)
摘 要:目的:采用HPLC法同时测定羌药川木香顺气丸中木香烃内酯和去氢木香内酯的含量。方法:色谱柱为Ultimate XB-C18色谱柱(4.6×250 mm,5μm),流动相为乙腈-0.2%甲酸水溶液(80:20,v/v),流速为1 ml.min-1,检测波长为225 nm,柱温为30℃。结果:木香烃内酯、去氢木香内酯分别在1.47~47.12、3.26~104.24μg.m L-1范围内呈良好的线性关系,川木香顺气丸中木香烃内酯、去氢木香内酯平均总含量为3.35mg/g。结论:实验所建立的HPLC方法可用于羌药川木香顺气丸中木香烃内酯和去氢木香内酯的含量测定。Objective: To establish an HPLC method for simultaneous determination of costunolide and dehydrocostus lactone in Qiang medicine Chuanmuxiang Shunqi pill. Method: Ultimate XB-C18(4.6×250 mm,5 μm) was adopted as the chromatographic column, with acetonitrile-0.2% formic acid water(80:20,v/v) as mobile phase. The fl ow rate was 1 m L.min-1, the detection wavelength was 225 nm and the column temperature was 30 ℃. Result: Costunolide and dehydrocostus lactone had a good linearity within the range of 1.47 μg.m L-1~47.12μg.m L-1, 3.26μg.m L-1~104.24 μg.m L-1 respectively. The total average content was 3.35mg/g. Conclusion: The method can be applied for the determination of costunolide and dehydrocostus lactone in the Qiang medicine Chuanmuxiang Shunqi pill, which provide the reference for quality evaluation of the medicine.
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