熏硫与未熏硫白芷抗炎镇痛作用的对比研究  

Comparative study on anti-inflammatory and analgesic effect of sulfur-fumigation and non-sulfur-fumigation Angelica dahurica

作　　者：卢晓琳[1,2] 蒋运斌[1] 袁茂华 曹赟 马逾英[1] 

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室四川省中药资源系统研究与开发利用重点实验室-省部共建国家重点实验室培育基地,四川成都611137 [2]四川农业大学农学院,四川成都611130

出　　处：《中药与临床》2015年第5期39-43,共5页Pharmacy and Clinics of Chinese Materia Medica

基　　金：国家"十一五"科技支撑计划(2007BAI40B02)

摘　　要：目的:阐明硫黄熏蒸对白芷药效作用的影响以及白芷主要药效物质基础。方法:选用经典的二甲苯致小鼠耳肿胀及醋酸致小鼠扭体法结合血浆HPLC图谱对熏硫与未熏硫白芷进行抗炎、镇痛的药效学对比实验。结果:未熏硫白芷高剂量表现出显著的抗炎、镇痛作用,熏硫白芷部分剂量组也显示出抗炎镇痛作用,但无统计学意义;抗炎、镇痛两个实验中所取得的各个剂量组的血浆成分类似;随着给药剂量的减小,各剂量组入血成分的峰面积也相应减小。结论:推测水合氧化前后内酯可能是白芷镇痛、抗炎的药效物质基础。本研究为阐明白芷谱效关系奠定了基础。Objective: To clarify the effect of sulfur-fumigation on efficacy of Angelica dahurica and elucidate the main effective material of Angelica dahurica. Method: Anti-inflammatory, analgesic effect of non-sulfur-fumigation and sulfurfumigation Angelica dahurica were tested with classic xylene induced ear swelling mice and acetic acid induced mice body torsion experiment combined with plasma HPLC fi ngerprint. Result: Non-sulfur-fumigation group showed signifi cant anti-infl ammatory and analgesic effects. No signifi cant anti-infl ammatory and analgesic effects can be observed in sulfur-fumigation group. Plasma composition of each dose group was similar. With the decrease of the dosage, the peak area of different dose groups also decreased accordingly. Conclusion: Oxypeucedanin hydrate is speculated to be the material basis of anti-infl ammatory effi cacy of Angelica dahurica, which lays a foundation for the elucidation of spectrum relationship of angelica dahurica.

关 键 词：白芷 熏硫 抗炎 镇痛 血浆药物化学 

分 类 号：R285.5[医药卫生—中药学]