二甲双胍对老年非糖尿病性高血压肾脏的保护  

Protective Effect of Metformin on Kidney in Non-diabetic Hypertension Elderly

作　　者：张勇[1] 周胜华[2] 樊光辉[1] 杜万红[1] 谭兵[1] 杨浩军[1] 

机构地区：[1]解放军第163医院,湖南长沙410003 [2]中南大学湘雅二院心血管内科

出　　处：《中国医师杂志》2003年第3期355-356,共2页Journal of Chinese Physician

摘　　要：目的　研究二甲双胍对老年非糖尿病性高血压肾脏的保护作用。方法　将患者分为硝苯地平及硝苯地平 +二甲双胍治疗二组 ,三个月后观察体重指数、血胰岛素、尿蛋白、尿素氮、血和尿 β2 微球蛋白的变化。结果　上述指标加二甲双胍组较单用硝苯地平组明显改善 (P <0 0 0 1)。结论　二甲双胍对老年高血压病的肾脏有保护作用。Objective To investigate the protection of metformin on kidney in non-diabetic hypertension elderly.Methods The patients was divided into two groups;one given nifedipine ,another given nifedipine plus metformin. Three months Later,the changes of body mass index (BMI), plasma insulin, urine protein, blood urea nitrogen(BUN), blood and urine β 2-microglobulin(β 2-MG) were examined. Results Above-markers were reduced more remarkably in nifedipine plus metformin group than that in only nifedipine group(P<0 001).Conclusion Metformin has protecting effects on kidney in the elderly hypertension.

关 键 词：二甲双胍 老年 非糖尿病性高血压 肾脏 保护 

分 类 号：R544.1[医药卫生—心血管疾病]