美洛西林血清杀菌与美洛西林/舒巴坦效价研究  

Serum Bactericidal Activities of Mezlocillin and Mezlocillin/sulbactam: A Comparative Study

作　　者：王培兰[1] 柴栋[1] 刘又宁[1] 王睿[1] 

机构地区：[1]解放军总医院,北京100853

出　　处：《中华医院感染学杂志》2003年第3期269-271,共3页Chinese Journal of Nosocomiology

摘　　要：目的　采用测定血清杀菌效价 (SBA)的方法评价美洛西林 /舒巴坦 (ML BT)与美洛西林 (ML XL)的体内抗菌活性。方法　 10名健康男性志愿者 ,采用随机分组 ,自身前后对照方法 ,分别静脉滴注 ML BT3.75 g、ML XL3.0 g,于给药后 0 .5 h(峰浓度 )、7h(谷浓度 )采血 ,测定 SBA。结果　 ML BT对产 β-内酰胺酶的金黄色葡萄球菌、表皮葡萄球菌、阴沟肠杆菌、大肠埃希菌的峰时 SBA均≥ 1∶ 8,为 ML XL 的 2～ 4倍 (P <0 .0 1) ;对产超广谱β-内酰胺酶 (ESBL s)的肺炎克雷伯菌、大肠埃希菌的血清杀菌活性为 ML XL 的 1～ 2倍 ;对铜绿假单胞菌 ,两药无差异。结论　 ML BT对临床常见产 β-内酰胺酶细菌的体内抗菌活性强于 ML XL,对治疗感染性疾病将会有更好的临床疗效。OBJECTIVE To determine the serum bactericidal activities(SBAs) of mezlocillin(MLXL) and mezlocillin/sulbactam(MLBJ) against clinical isolates. METHODS A randomized self control clinical study was performed in 10 healthy male volunteers, 3.75 g or 3.0 g was administered by iv. To contrast the SBAs of both them, the blood samples were taken in 0.5 h and 7 h after administration. RESULTS The peak SBAs of MLBT against β lactamase positive Staphylococcas aureus, S. epidermidis, Enterococcus cloacae, Escherichia coli were higher than mezlocillin by 2 4 times. The peak SBAs of MLBT against ESBLs positive Klebsiella pneumoniae and E.coli were slightly stronger than MLXL by 1 2 times. There was no significant difference against Pseudomonas aeruginosa between MLBT and MLXL. CONCLUSIONS In vivo the antibacterial activities of MLBT against clinical β lactamase positive isolates are stronger than MLXL.

关 键 词：美洛西林 舒巴坦 血清杀菌活性 

分 类 号：R979.7[医药卫生—药品]