黄蜀葵总黄酮对大鼠急性不完全脑缺血损伤的保护作用  

Protection effects of the total flavone from abelmoschus maniho L medic on acute incompletely cerebral ischemia in rats

作　　者：高杉[1] 范丽[1] 董六一[1] 岑德意[1] 江勤[1] 方明[1] 陈志武[1] 

机构地区：[1]安徽医科大学药理学教研室

出　　处：《中国临床药理学与治疗学》2003年第2期167-169,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：安徽省教育厅科研项目 № :2 0 0 3kj2 2 4

摘　　要：目的 :研究黄蜀葵总黄酮 (TFA)对大鼠急性不完全脑缺血损伤的保护作用。方法 :60只Wistar大鼠随机分成假手术组、生理盐水 (NS)对照组、TFA组和EGB阳性对照组 ,采用结扎双侧颈总动脉制作急性不完全性脑缺血模型 ,观察脑缺血后脑组织含水量、脑血管通透性和病理学改变。结果 :5 0 ,10 0mg·kg-1TFA和 10 0mg·kg-1EGB ,可明显抑制脑水肿的发生 ,与NS组相比 ,可明显改善脑组织病理学的改变。结论AIM: To investigate the protection effect of the total flavone from abelmoschus maniho L medic (TFA) on acute incompletely cerebral ischemia in rats. METHODS: The percentage of cerebral tissue water bearing, permeability of cerebral vessel (OD tite), and pathology changes of cerebrum tissue were detected before and after the treatment of TFA. Ginkgo biloba extract, NS and sham operation were set as controls. RESULTS: In the acute incomplete cerebral ischemia models, TFA (50、100 mg·kg -1 , ig) could obviously reduce the water in the cerebrum in rats, and improve the pathology changes of cerebrum tissue in comparison with NS group. CONCLUSION: TFA shows a protective role on incomplete cerebral ischemia injury in rats.

关 键 词：药理学 黄蜀葵 中药 药理 总黄酮 脑缺血 动物模型 

分 类 号：R285.5[医药卫生—中药学]