苯妥英锌对烧伤的临床治疗作用  

Clinical observation of phenytoin zinc in the treatment of patients with burns

作　　者：蒲其松[1] 李保国[2] 张翔[1] 陈发国[2] 

机构地区：[1]川北医学院药理教研室 [2]石河子医学院附属医院烧伤科

出　　处：《中国临床药理学与治疗学》2003年第2期192-194,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :观察苯妥英锌治疗烧伤的作用。方法 :选择烧伤部位的面积和深度相近的 19例Ⅱ度烧伤患者 ,分为两组 ,分别用苯妥英锌和磺胺嘧啶银的软膏 (2 5 % )外用治疗 ,观察创面肿胀程度、发炎、创面结痂、局部疼痛以及创面愈合时间 ,并进行烧伤后创面组织学检查。结果 :苯妥英锌组创面的渗出比对照组少 ,疼痛明显减轻 (P <0 .0 5 ) ,创面细菌的转阴率 1wk后为 30 % (对照组为 33.3% ) ,创面愈合时间为 16.1± 2 .8d(对照组为 16.8± 2 .7d) ,创面毛细血管胚芽与成纤维细胞数量明显多于对照组。结论AIM: To observe the effect of phenytoin zinc in treatment of patients with burns. METHODS: Phentyoin zinc (PZ) was compared with sulfadiazine silver(SS) in the treatment of burns. Nineteen patients with second degree burns were enrolled. Ten were in PZ group and nine in SS group,and the drugs were made in a formula of 25% vaseline ointment spread on the wound surface of burns. During the period of treatment, the bacterial burn surface was cultured weekly. Pain, swollen, exudation, inflammation, scab, and healing time of the wounds were observed as well as histological examination. RESULTS: In PZ group, exudation was decreased and rapid elimination of wound pain (P< 0.05 ) compared to SS group. Bacterial burn surface culture became negative one week after treatment accounted for 30% in PZ group. There were 16.1 ± 2.8 d of healing time of the wounds in PZ group. PZ promoted the granulation tissue proliferation. CONCLUSION: PZ has much better than, at least the equivalent effect, SS in the treatment of patients with burns.

关 键 词：治疗作用 药效学 苯妥英锌 磺胺嘧啶根 烧伤 

分 类 号：R644.05[医药卫生—外科学]