芪丹通脉片预防异丙肾上腺素所致的大鼠慢性心肌缺血  

Preventive effects and mechanism of Qidantongmai tablet on isoproterenol caused chronic myocardial infarction in mice

作　　者：李晶华[1] 王宗仁[1] 肖铁卉[1] 邵中军[2] 马静[1] 郑谨[1] 马爱玲[1] 龙铟[1] 王文[1] 李军昌[1] 

机构地区：[1]第四军医大学西京医院中医科,陕西西安710033 [2]第四军医大学预防医学系流行病学教研室,陕西西安710033

出　　处：《第四军医大学学报》2003年第5期397-399,共3页Journal of the Fourth Military Medical University

基　　金：陕西省重点科研项目资助课题 (2 0 0 1k1 2 G7)

摘　　要：目的 :研究芪丹通脉片 (QDTMT)对大鼠慢性心肌缺血预防作用及其机制 .方法 :采用SD大鼠为研究对象 ,比较观察QDTMT长期小剂量给药对异丙肾上腺素所致的心肌缺血保护作用 ,通过检测心肌血管内皮生长因子 (VEGF)、碱性成纤维细胞生长因子 (bFGF)表达 ,探讨其可能作用机制 .结果 :未注射ISO组未见VEGF ,bFGF表达 ,而在注射异丙肾上腺素 (Iso)各组VEGF ,bFGF表达均增加 ,给药组VEGF ,bFGF表达量高于未给药组 .结论 :QDTMT能够预防慢性心肌缺血 ,促进VEGF 。AIM: To investigate the preventive effects of Qidantongmai tablet on chronic myocardial infarction in mice and its possible mechanism. METHODS: Wistar mice were given small-dose of Qidantongmai Tablet to see the preventive effects on isoproterenol (ISO) caused chronic myocardial infarction, and the contents of VEGF and bFGF in the part of ischemia were detected by immunohistochemistry method to explore its mechanism. RESULTS: No expression of VEGF and bFGF was found in the group of non-injection ISO, but in ISO injection groups QiDanTongMai Tablet enhanced the expression of VEGF and bFGF. CONCLUSION: Qidantongmai tablet can prevent chronic myocardial ischemia and the acceleration of the expression of VEGF and bFGF may be responsible for it.

关 键 词：芪丹通脉片 慢性心肌缺血 血管内皮生长因子 碱性成纤维细胞生长因子 中医药疗法 

分 类 号：R259.422[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]