冠心病患者血清血管内皮生长因子水平与冠状动脉病变程度的关系  

Correlation between serum level of vascular endothelial growth factor and severity of coronary artery stenosis in patients with coronary heart disease

作　　者：韦方[1] 耿庆山 周钢[3] 符永恒[3] 谭红红 余细勇[3] 

机构地区：[1]贵州省人民医院心内科,贵阳550002 [2]广东省心血管病医院心内科 [3]广东省心血管病研究所分子药理室

出　　处：《临床心血管病杂志》2003年第3期132-133,共2页Journal of Clinical Cardiology

摘　　要：目的 :探讨冠心病 (CHD)患者血清血管内皮生长因子 (VEGF)水平与冠状动脉病变的关系。方法 :采用酶联免疫吸附法 (ELISA)检测了 12 4例经冠状动脉造影证实有一支以上主要冠状动脉狭窄≥ 5 0 %的CHD患者血清VEGF水平 ,并作相关分析。结果 :CHD组血清VEGF水平明显高于正常对照组〔(2 93.2± 12 6 .3)ng/L∶(12 0 .1± 31.5 )ng/L ,P <0 .0 1〕 ,双支和三支血管病变患者血清VEGF水平高于单支组〔(2 83.4± 85 .0 )ng/L ,(398.1± 10 5 .5 )ng/L∶ (191.7± 2 7.3)ng/L ,P <0 .0 1〕 ,随着血管狭窄程度的加重 ,血清VEGF水平升高越明显 ,两者呈显著正相关 (r =0 .78,P <0 .0 0 1) ,CHD并发高血压和 (或 )糖尿病对血清VEGF水平无显著影响 (P >0 .0 5 )。结论 :CHD患者血清VEGF水平升高 。Objective:To investigate the correlation between serum level of vascular endothelial growth factor(VEGF) and the severity of coronary artery stenosis in patients with coronary heart disease( CHD). Methods:Serum level of VEGF in 124 CHD patients were measuneal and compared with that of 90 normal control subjects.Results:The serum levels of in VEGF in CHD patients were significantly elevated as compared with that of control subjects〔( 293.2 ± 126.3 )ng/L vs( 120.1 ± 31.5 )ng/L, P< 0.01 〕. Among CHD group, patients with stenosis lesion in 2 or 3 branches of coronary artery had higher VEGF level〔( 283.4 ± 85.0 )ng/L,( 398.1 ± 105.5 )ng/L Vs ( 191.7 ± 27.3 )ng/L, P< 0.01 〕, and serum VEGF concentration were positively correlated with the severity of coronary artery stenosis(r= 0.78 , P< 0.001 ). Conclusion:Serum levels of VEGF in patients with CHD are elevated, it reflects the severity of coronary artery disease.

关 键 词：冠心病 冠状动脉疾病 血管内皮生长因子 病理 

分 类 号：R541.402[医药卫生—心血管疾病]