氢溴酸高乌甲素的抗心律失常作用  

Study on the effects of Gao-Wu hydrobromide tablet on Experimental Arrhythmia

作　　者：孔古娅[1] 卿德华[1] 楚延[1] 

机构地区：[1]四川大学华西基础医学与法医学院,成都610041

出　　处：《四川生理科学杂志》2002年第4期175-177,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的 :研究氢溴酸高乌甲素 (QingxiusuanGaowujiasuQG)的抗心律失常作用。 方法 :采用静脉推注乌头碱 (AconitiACO)诱发大鼠心律失常及结扎犬冠状动脉造成缺血性心律失常模型。结果 :氢溴酸高乌甲素口服 6.0mg/kg、3 .0mg/kg、1 .5mg/kg ,静脉注射 0 .9nmg/kg、0 .45mg/kg、0 .3mg/kg能有效提高乌头碱诱发大鼠心律失常的阈值 ,口服 6.0mg/kg、1 .5mg/kg ,静脉注射 0 .9mg/kg、0 .3mg/kg ,能显著改善犬心肌缺血性心律失常 ,降低心律失常的发生率。结果 :氢溴酸高乌甲素有明显的抗心律失常作用。Objective: To study the effect of Gao Wu hydrobromide tablet on anti arrhythmia. Methods: Model of arrhythmia in rats induced by intravenous injection of aconiti and myocardial ischemia arrhythmia in dogs caused by ligating coronari. Results: Both oral mediction and intravenous injection of GWHB can effectually raise the dosage of Aconiti that were used to evoke arrhythmia in rats as well as in dogs, and also can greatly decrease the occurrence of myocardial ischemia arrhythmia in dogs. Conclusion: Gao Wu A hydrobromide tablet revealed an effective effect on anti arrhythmia in animal models.

关 键 词：实验研究 氢溴酸高乌甲素 抗心律失常 

分 类 号：R285.5[医药卫生—中药学]