应激性大鼠肾小球入、出球小动脉口径的比较研究  

Compare research of the calibers of enter and out kidney-glomerular arteries in stress rats

作　　者：尹艳茹[1] 郭家松[2] 周洁[3] 

机构地区：[1]第一军医大学分校生理学教研室,广州510315 [2]第一军医大学分校解剖学教研室,广州510315 [3]第一军医大学分校病理学教研室,广州510315

出　　处：《第一军医大学分校学报》2002年第2期89-91,共3页Journal of Branch Campus of the First Military Medical University

基　　金：广东省医学科学技术研究基金资助项目 (NO .A19994 82 )

摘　　要：目的　研究应激性大鼠血压升高时肾脏结构的变化。方法　给SD大鼠间断性足底电刺激 15d ,隔日监测尾动脉血压 (BP) 1次 ,观察其尾动脉BP的变化情况和第 15天后肾脏肾小球入球小动脉和出球小动脉口径的变化。结果　单纯应激组在第 9、11、13、15天测得BP与对照组相比有明显差异 (P <0 .0 5或P <0 .0 1) ;第 15天后肾脏肾小球入球小动脉和出球小动脉口径的变化与对照组相比没有明显区别 (P >0 .0 5 )。L -ARG +应激组隔日测得BP与对照组相比没有明显差异 ,第 15天测得BP低于对照组 (P <0 .0 5 ) ,BP未升高 ,且有下降的趋势 ,第 15天后肾小球入球小动脉和出球小动脉口径的变化与对照组相比没有明显区别 (P >0 .0 5 )。结论　应激刺激可使BP升高 ,应激性大鼠血压升高的早期肾脏入、出球小动脉结构没有明显变化。Objective To investigate the change of the cailbers of enter and out kidney-glomerular arteries when Blood Press (BP) of stress rats are high. Methods All the Sprague-Dawley rats were divided into three groups: stress group, L-anginine+stress group and control group. L-ARG were added into drinking water in the L-ARG+Stress group and electric stimulus in foot-plant were given intermittently to the L-ARg+stress gruoup and the stress group for 15 day. BP of tail artery was measured every two days, and the calibers of enter and out kidmey -glomerular arteries were measured at the 15th day. Results There were significant differences of BP between control group and stress group on the 9th ?11th?13th?15th day( P <0.05 or P <0.01). After stimulus,the level of BP increased, while the calibers of emter and out kidney-glomerular arteries did not chang ( P >0.05).The differences of BP between control group and the L-ARG+stress group were not remarkabel until the 15th day. BP of L-ARG+stress group was lower than that of control group on the 15th day ( P <0.05).The calibers of enter and out kidney-glomerular arteries did not chang ( P >0.05). Conclusion The present results indicate that BP would increase after stress, but the calibers of enter and out kidney-glomerular arteries remain unchanged in early stage of stress.

关 键 词：应激性 大鼠 口径 比较研究 肾小球入球小动脉 肾小球出球小动脉 血压 

分 类 号：R692[医药卫生—泌尿科学]