探讨血浆纤维蛋白原单体聚合功能在妊高征中的临床意义  

Determination of Plasma Fibrinogen Monomer Polymerization Function in Pregnancy Induced Hypertension

作　　者：周莉[1] 高眉扬[1] 饶安娜[1] 张兰珍[1] 廖志琼[1] 许梅艳[1] 

机构地区：[1]广州医学院第二附属医院妇产科,广州510260

出　　处：《广州医学院学报》2002年第4期30-32,共3页Academic Journal of Guangzhou Medical College

摘　　要：目的 :研究妊高征患者血浆纤维蛋白原单体聚合功能的临床意义。方法 :用蕲蛇酶 (Acutulase)水解纤维蛋白原 ,采用计算机自动检测系统对 70例正常晚期妊娠妇女和 6 0例妊高征患者进行定量检测。结果 :轻度妊高征组的血浆纤维蛋白原单体聚合反应速率 (FMPV)、血浆凝固性纤维蛋白原含量 (S)和最大吸光度 (Amax)分别为 0 77± 0 .10 ,(45 2 .33± 85 .96 )mg/dL ,0 .4 0± 0 .0 5 ,明显高于对照组 [0 .6 6± 0 .15 ,(370 .89± 112 .2 0 )mg/dL ,0 .35± 0 .0 8],差异有显著性 (P <0 .0 5 ) ;重度妊高征组分别为 0 .5 7± 0 .14 ,(30 8.4 5± 93.97)mg/mL ,0 .30± 0 .0 8,明显低于对照组 (P <0 .0 5 ) ,且显著低于轻度妊高征组 (P≤ 0 .0 0 1)。结论 :应用计算机自动检测系统动态监测纤维蛋白原单体聚合功能 ,对妊高征的凝血功能状态及并发症的判断及指导治疗 ,具有一定的临床价值。Objective: To study the changes and the clinical significance of Plasma fibrinogen monomer polymerization function in PIH. Method: The fibrinogen was hydrolyzed by acutulase and detected by automatic computer detection system. 130 cases were measured,including 70 normal pregnant women (at gestational weeks 29～40) and the 60 patients with PIH. Result: The levels of plasma fibrin monomer polymerization reaction speed(FMPV),plasma fibrinogen concentration(S) and maximum attraction luminosity (A max ) in mild PIH were (0.77±0.10),(452.33±85.96 mg/dL) and (0.40±0.05),which were markedly higher than that of the normal pregnant subjects[(0.66±0.15), P <0.05],[(370.89±112.20) mg/dL, P <0.05] and [(0.35±0 08), P <0 05].The value in preeclampsia were (0.57±0.14),(308.45±93.97 mg/dL) and (0.30±0.08),which were markedly lower than that of control subjects ( P <0.05) and significantly lower than that of mild PIH( P ≤0.001). Conclusion: This study showed that detection of Plasma fibrinogen monomer polymerization function with automatic computer system might be helpful for determining coagulating function,complications and treatment strategies in PIH.

关 键 词：妊娠高血压综合征 血浆 纤维蛋白原 单体聚合功能 临床意义 

分 类 号：R714.246[医药卫生—妇产科学]