胃起搏治疗手术后胃动力障碍的实验研究  

An Experimental Study of Gastric Pacing on Postsurgical Gastric Dynamic Dysfunction

作　　者：李富宇[1] 于运海 何生[1] 毛辉[1] 

机构地区：[1]四川大学华西医院普外科,610041 [2]黑龙江省讷河市第一人民医院

出　　处：《四川大学学报（医学版）》2003年第2期322-324,共3页Journal of Sichuan University(Medical Sciences)

摘　　要：目的　探讨胃起搏在手术后胃动力障碍治疗中的可行性及疗效。方法　对迷走神经干切断术后急性胃轻瘫的动物模型分别应用胃起搏及静注红霉素 (1mg/ kg) ,比较胃动力学指标变化。结果　胃起搏组及红霉素组的胃、十二指肠压力及胃窦 -十二指肠压力差均高于起搏前基础压 (P<0 .0 0 1) ;胃起搏组胃内压及胃窦 -十二指肠压力差均高于红霉素组 (P<0 .0 0 1) ;两组的十二指肠压无显著性差异 (P>0 .0 5 ) ;起搏组停起搏 2 0 m in后胃内压虽有下降趋势 ,但此时的胃底压、胃体压、胃窦压仍高于红霉素组 (P分别 <0 .0 1,<0 .0 5 ,<0 .0 5 ) ;胃起搏 2 h的胃排空率 (6 4 .4 1± 6 .6 6 % )高于静注红霉素 2 h的胃排空率 (5 3.73%± 7.0 7% ) (P<0 .0 1)。结论　高频胃起搏能明显增加胃内压、胃窦 -十二指肠压力差及胃排空率 。Objective To probe the feasibility and curative effect of gasttric pacing on postsurgical gastric dynamic dysfunction. Thirty two rabbits were divided into four groups. The gastric dynamic indices of applying gastric pacing to the experimental animal model of acute post vagotomy gastroparesis were compared with those of the groups treated with erythromycin (1 mg/kg). Results The measurements of 'gastroduodenal pressure at different sites' of the gastric pacing group and erythromycin group were higher than those of the before pacing group respectively ( P <0 001). The gastric pressure of the gastric pacing group was higher than that of the erythromycin group ( P <0 001). No significant difference in the duodenal pressure was observed between the above two groups ( P >0 05). The measurements of pressure at different sites (gastric fundus; gasric corpus; gastric antrum) after stopping pacing were higher than those of the erythromycin group, respectively ( P <0 01, P < 0 05, P <0 05). The 'pressure gradient betwen gastric antrum and duodenum' of the gasric pacing group was higher than that of the erythromycin group ( P <0 01). The gastric emptying rate of the gastric pacing group (64 41%±6 66%) was significantly higher than that of the erythromycin group (53.73%±7.09%) ( P <0 01). Conclusion Applying higher frequency gastric pacing can markedly enhance the gastric pressure, the pressure gradient betwen gastric antrum and duodenum, and the gasric emptying rate.

关 键 词：胃起搏 胃动力学 术后胃轻瘫 红霉素 

分 类 号：R656.61[医药卫生—外科学]