夜间哮喘呼气流速峰值及呼吸驱动昼夜节律的研究  

Study on circadian rhythm of PEF and respiratory drive in nocturnal asthma

作　　者：赵海燕[1] 陈宝元[1] 郭美南[1] 

机构地区：[1]天津医科大学总医院呼吸科,天津300052

出　　处：《天津医科大学学报》2003年第1期27-28,32,共3页Journal of Tianjin Medical University

摘　　要：目的 :探讨夜间哮喘(nocturnalasthma,NA)患者呼气流速峰值与呼吸驱动的昼夜节律及二者的相关性。方法 :研究对象分3组 :夜间哮喘组(n=10)、哮喘非夜间发作组(n=10)、健康对照组 (n=10)。采用西德CUSTO肺功能仪及Jaeger呼吸驱动测试仪分别于4时、8时、16时、22时测定肺功能———呼气流速峰值(PEF)及呼吸驱动———气道闭合压 (P0.1)。结果 :夜间哮喘组和健康对照组PEF均于16时达峰值 ,4时降到最低 ,夜间哮喘组最高值与最低值之间差异有显著性(P<0.01) ,健康对照组无显著差异(P>0.05)。哮喘非夜间发作组夜间PEF无降低。3组P0.1 均未发现明显昼夜节律。PEF与呼吸驱动亦无显著相关性(P>0.05)。结论 :夜间哮喘患者PEF呈昼夜节律改变 ,P0.1 未发现明显昼夜节律 ,且二者无显著相关性。Objective:The aim of this study is to investigate the circadian rhythm of PEF and respiratory drive in nocturnal asthma.Methods:PEF and P 0.1 were measured at04:00,08:00,16:00,22:00in three groups:nocturnal asthma(n=10),non-nocturnal asthma(n=10)and healthy control subjects(n=10).Results:Both in nocturnal asthmatic group and control group,PEF was highest at16:00and lowest at04:00.In nocturnal asthma the difference was significant(P<0.01).In control group,the difference was not significant(P>0.05).In non-nocturnal asthma PEF did not decrease at night.P 0.1 did not take on circadian rhythm in all three groups.Conclusion:In nocturnal asthma,PEF takes on circadian rhythm.P 0.1 does not take on significant circadian rhythm in all three groups.

关 键 词：夜间哮喘 呼气流速峰值 呼吸驱动 昼夜节律 

分 类 号：R562.25[医药卫生—呼吸系统]